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List of Substances on IRIS

List A to Z

Final IRIS assessments in alphabetical order by chemical name. Additional information can be downloaded by visiting the IRIS Advanced Search feature. The "Last Significant Revision" column refers to the most recent statement of or change to a toxicity value [RfD, RfC, slope factor or unit risk], or most recent significant statement of or change to the basis or justification for the conclusions in the assessment. This column is provided for the convenience of the IRIS user. For specific information, see the Revision History for each substance.
A basic version of this table is available.
Row Chemical Name CASRN Last Significant Revision Literature Screening Review Critical Effect Systems RfD Value (Chronic) RfD Value (Subchronic) RfC Value (Chronic) RfC Value (Subchronic) Tumor Site Pesticide Archive
1 Acenaphthene 83-32-9 19901101 Nov-01-1990 No Hepatic
6 x 10 -2 mg/kg-day None
2 Acenaphthylene 208-96-8 19910101 Jan-01-1991 No None None
3 Acephate 30560-19-1 19890501 May-01-1989 Yes Nervous
4 x 10 -3 mg/kg-day Hepatic
pesticide archive
4 Acetaldehyde 75-07-0 19911001 Oct-01-1991 No
Nervous
Respiratory
9 x 10 -3 mg/m3 Respiratory
5 Acetochlor 34256-82-1 19930901 Sep-01-1993 Yes
Hematologic
Hepatic
Nervous
Reproductive
Urinary
2 x 10 -2 mg/kg-day None pesticide
6 Acetone 67-64-1 20030731 Jul-31-2003 No Urinary
9 x 10 -1 mg/kg-day None
7 Acetonitrile 75-05-8 19990303 Mar-03-1999 No None 6 x 10 -2 mg/m3 None
8 Acetophenone 98-86-2 19910201 Feb-01-1991 Yes None 1 x 10 -1 mg/kg-day None
9 Acetyl chloride 75-36-5 19910301 Mar-01-1991 No None None
10 Acifluorfen, sodium 62476-59-9 19870331 Mar-31-1987 Yes
Developmental
Urinary
1.3 x 10 -2 mg/kg-day None pesticide
11 Acrolein 107-02-8 20030603 Jun-03-2003 No Respiratory
5 x 10 -4 mg/kg-day 2 x 10 -5 mg/m3 None
12 Acrylamide 79-06-1 20100322 Mar-22-2010 No Nervous
2 x 10 -3 mg/kg-day 6 x 10 -3 mg/m3
Endocrine
Reproductive
13 Acrylic acid 79-10-7 19940401 Apr-01-1994 Yes
Developmental
Nervous
Respiratory
5 x 10 -1 mg/kg-day 1 x 10 -3 mg/m3 None
14 Acrylonitrile 107-13-1 19911101 Nov-01-1991 Yes Respiratory
2 x 10 -3 mg/m3
Gastrointestinal
Nervous
Respiratory
15 Adiponitrile 111-69-3 19910201 Feb-01-1991 Yes None None
16 Alachlor 15972-60-8 19930901 Sep-01-1993 No Hematologic
1 x 10 -2 mg/kg-day None pesticide
17 Alar 1596-84-5 19880630 Jun-30-1988 Yes None 1.5 x 10 -1 mg/kg-day None pesticide
18 Aldicarb 116-06-3 19931101 Nov-01-1993 Yes Nervous
1 x 10 -3 mg/kg-day None pesticide
19 Aldicarb sulfone 1646-88-4 19931101 Nov-01-1993 Yes Nervous
1 x 10 -3 mg/kg-day None
20 Aldrin 309-00-2 19870930 Sep-30-1987 Yes Hepatic
3 x 10 -5 mg/kg-day Hepatic
pesticide
21 Ally 74223-64-6 19880630 Jun-30-1988 Yes None 2.5 x 10 -1 mg/kg-day None pesticide
22 Allyl alcohol 107-18-6 19870131 Jan-31-1987 Yes
Hepatic
Urinary
5 x 10 -3 mg/kg-day None
23 Allyl chloride 107-05-1 19911201 Dec-01-1991 Yes Nervous
1 x 10 -3 mg/m3 None
24 Aluminum phosphide 20859-73-8 19870131 Jan-31-1987 Yes None 4 x 10 -4 mg/kg-day None pesticide
25 Amdro 67485-29-4 19870930 Sep-30-1987 Yes Hepatic
3 x 10 -4 mg/kg-day None pesticide archive
26 Ametryn 834-12-8 19870930 Sep-30-1987 Yes Hepatic
9 x 10 -3 mg/kg-day None pesticide
27 4-Aminopyridine 504-24-5 19891201 Dec-01-1989 Yes None None pesticide
28 Amitraz 33089-61-1 19880822 Aug-22-1988 Yes Hematologic
2.5 x 10 -3 mg/kg-day None pesticide
29 Ammonia 7664-41-7 20160920 Sep-20-2016 Yes Respiratory
5 x 10 -1 mg/m3 None
30 Ammonium acetate 631-61-8 19910301 Mar-01-1991 No None None
31 Ammonium methacrylate 16325-47-6 19910301 Mar-01-1991 No None None
32 Ammonium sulfamate 7773-06-0 19890101 Jan-01-1989 Yes None 2 x 10 -1 mg/kg-day None
33 Aniline 62-53-3 19901101 Nov-01-1990 Yes Hematologic
1 x 10 -3 mg/m3 Immune
34 ortho-Anisidine 90-04-0 19911001 Oct-01-1991 Yes None None archive
35 Anthracene 120-12-7 19910101 Jan-01-1991 No None 3 x 10 -1 mg/kg-day None
36 Antimony 7440-36-0 19870131 Jan-31-1987 Yes Hematologic
4 x 10 -4 mg/kg-day None
37 Antimony trioxide 1309-64-4 19950901 Sep-01-1995 Yes Respiratory
2 x 10 -4 mg/m3 None
38 Apollo 74115-24-5 19910601 Jun-01-1991 Yes
Endocrine
Hepatic
1.3 x 10 -2 mg/kg-day None pesticide
39 Aramite 140-57-8 19910601 Jun-01-1991 Yes None Hepatic
40 Aroclor 1016 12674-11-2 19930101 Jan-01-1993 No Developmental
7 x 10 -5 mg/kg-day None
41 Aroclor 1248 12672-29-6 19940401 Apr-01-1994 No None None
42 Aroclor 1254 11097-69-1 19941001 Oct-01-1994 No
Dermal
Immune
Ocular
2 x 10 -5 mg/kg-day None
43 Arsenic, Inorganic 7440-38-2 19950601 Jun-01-1995 Yes
Cardiovascular
Endocrine
6 x 10 -5 mg/kg-day
Respiratory
Urinary
44 Arsine 7784-42-1 19940301 Mar-01-1994 Yes
Hematologic
Immune
5 x 10 -5 mg/m3 None
45 Asbestos 1332-21-4 19880926 Sep-26-1988 No None Respiratory
46 Assure 76578-14-8 19910601 Jun-01-1991 Yes Hepatic
9 x 10 -3 mg/kg-day None pesticide
47 Asulam 3337-71-1 19880630 Jun-30-1988 Yes
Hepatic
Reproductive
5 x 10 -2 mg/kg-day None pesticide archive
48 Atrazine 1912-24-9 19931001 Oct-01-1993 Yes None 3.5 x 10 -2 mg/kg-day None pesticide
49 Avermectin B1 65195-55-3 19890701 Jul-01-1989 Yes Developmental
4 x 10 -4 mg/kg-day None pesticide
50 Azobenzene 103-33-3 19880907 Sep-07-1988 Yes None None
51 Barium and Compounds 7440-39-3 20050711 Jul-11-2005 Yes Urinary
2 x 10 -1 mg/kg-day None
52 Barium cyanide 542-62-1 19910301 Mar-01-1991 No None None archive
53 Baygon 114-26-1 19870930 Sep-30-1987 Yes Nervous
4 x 10 -3 mg/kg-day None pesticide
54 Bayleton 43121-43-3 19880301 Mar-01-1988 Yes Hematologic
3 x 10 -2 mg/kg-day None pesticide archive
55 Baythroid 68359-37-5 19880301 Mar-01-1988 Yes Urinary
2.5 x 10 -2 mg/kg-day None pesticide
56 Benefin 1861-40-1 19870331 Mar-31-1987 Yes Hematologic
3 x 10 -1 mg/kg-day None pesticide archive
57 Benomyl 17804-35-2 19870131 Jan-31-1987 Yes Developmental
5 x 10 -2 mg/kg-day None pesticide
58 Bentazon (Basagran) 25057-89-0 19980302 Mar-02-1998 Yes Hematologic
3 x 10 -2 mg/kg-day None pesticide
59 Benz[a]anthracene 56-55-3 19901201 Dec-01-1990 No None None
60 Benzaldehyde 100-52-7 19880907 Sep-07-1988 Yes
Gastrointestinal
Urinary
1 x 10 -1 mg/kg-day None
61 Benzene 71-43-2 20030417 Apr-17-2003 No Immune
4 x 10 -3 mg/kg-day 3 x 10 -2 mg/m3 Hematologic
62 Benzidine 92-87-5 19910701 Jul-01-1991 Yes
Hepatic
Nervous
3 x 10 -3 mg/kg-day Urinary
63 Benzo[a]pyrene (BaP) 50-32-8 20170119 Jan-19-2017 No
Developmental
Immune
Reproductive
3 x 10 -4 mg/kg-day 2 x 10 -6 mg/m3
Gastrointestinal
Respiratory
64 Benzo[b]fluoranthene 205-99-2 19901201 Dec-01-1990 No None None
65 Benzo[g,h,i]perylene 191-24-2 19901201 Dec-01-1990 No None None
66 Benzo[k]fluoranthene 207-08-9 19901101 Nov-01-1990 No None None
67 Benzoic acid 65-85-0 19890801 Aug-01-1989 Yes None 4 mg/kg-day None
68 Benzotrichloride 98-07-7 19900701 Jul-01-1990 No None Respiratory
69 Benzyl chloride 100-44-7 19920101 Jan-01-1992 Yes None Endocrine
70 Beryllium and compounds 7440-41-7 19980403 Apr-03-1998 Yes
Gastrointestinal
Immune
Respiratory
2 x 10 -3 mg/kg-day 2 x 10 -5 mg/m3 Respiratory
71 Bidrin 141-66-2 19870930 Sep-30-1987 Yes Reproductive
1 x 10 -4 mg/kg-day None pesticide archive
72 Biphenthrin 82657-04-3 19880822 Aug-22-1988 Yes Nervous
1.5 x 10 -2 mg/kg-day None pesticide
73 Biphenyl 92-52-4 20130827 Aug-27-2013 Yes Urinary
5 x 10 -1 mg/kg-day Hepatic
74 Bis(2-chloro-1-methylethyl) ether 108-60-1 19891001 Oct-01-1989 Yes Hematologic
4 x 10 -2 mg/kg-day None
75 Bis(2-chloroethoxy)methane 111-91-1 19910301 Mar-01-1991 Yes None None
76 Bis(chloroethyl)ether (BCEE) 111-44-4 19911001 Oct-01-1991 Yes None Hepatic
77 Bis(chloromethyl)ether (BCME) 542-88-1 19910701 Jul-01-1991 Yes None Respiratory
78 Bisphenol A 80-05-7 19880926 Sep-26-1988 Yes None 5 x 10 -2 mg/kg-day None
79 Boron and Compounds 7440-42-8 20040805 Aug-05-2004 No Developmental
2 x 10 -1 mg/kg-day None
80 Bromate 15541-45-4 20010606 Jun-06-2001 No Urinary
4 x 10 -3 mg/kg-day
Endocrine
Reproductive
Urinary
81 Brominated dibenzofurans None 19901201 Dec-01-1990 No None None
82 Bromobenzene 108-86-1 20090930 Sep-30-2009 No Hepatic
8 x 10 -3 mg/kg-day 2 x 10 -2 mg/kg-day 6 x 10 -2 mg/m3 2 x 10 -1 mg/m3 None
83 Bromochloromethane 74-97-5 19910301 Mar-01-1991 No None None
84 Bromodichloromethane 75-27-4 19930201 Feb-01-1993 Yes Urinary
2 x 10 -2 mg/kg-day Urinary
85 p-Bromodiphenyl ether 101-55-3 19900801 Aug-01-1990 No None None
86 Bromoform 75-25-2 19931201 Dec-01-1993 Yes Hepatic
2 x 10 -2 mg/kg-day Gastrointestinal
87 Bromomethane 74-83-9 19920401 Apr-01-1992 Yes
Gastrointestinal
Nervous
Respiratory
1.4 x 10 -3 mg/kg-day 5 x 10 -3 mg/m3 None
88 Bromotrichloromethane 75-62-7 19910301 Mar-01-1991 Yes None None
89 Bromoxynil 1689-84-5 19880630 Jun-30-1988 No None 2 x 10 -2 mg/kg-day None pesticide archive
90 Bromoxynil octanoate 1689-99-2 19880907 Sep-07-1988 Yes None 2 x 10 -2 mg/kg-day None pesticide archive
91 1,3-Butadiene 106-99-0 20021105 Nov-05-2002 No Reproductive
2 x 10 -3 mg/m3 Hematologic
92 n-Butanol 71-36-3 19910301 Mar-01-1991 Yes Nervous
1 x 10 -1 mg/kg-day None
93 tert-Butyl Alcohol (tBA) 75-65-0 20210813 Aug-13-2021 No Urinary

Endocrine
Urinary
94 Butyl benzyl phthalate (BBP) 85-68-7 19890901 Sep-01-1989 Yes Hepatic
2 x 10 -1 mg/kg-day None
95 Butylate 2008-41-5 19941001 Oct-01-1994 Yes Hepatic
5 x 10 -2 mg/kg-day None pesticide
96 t-Butylchloride 507-20-0 19900401 Apr-01-1990 No None None
97 Butylphthalyl butylglycolate (BPBG) 85-70-1 19870301 Mar-01-1987 No None 1 mg/kg-day None
98 Cacodylic acid 75-60-5 19921101 Nov-01-1992 Yes None None pesticide
99 Cadmium 7440-43-9 19891001 Oct-01-1989 No Urinary
5 x 10 -4 mg/kg-day Respiratory
100 Calcium cyanide 592-01-8 20100928 Sep-28-2010 Yes Reproductive
1 x 10 -3 mg/kg-day None
101 Caprolactam 105-60-2 19940901 Sep-01-1994 Yes Developmental
5 x 10 -1 mg/kg-day None
102 Captafol 2425-06-1 19870930 Sep-30-1987 Yes Urinary
2 x 10 -3 mg/kg-day None pesticide
103 Captan 133-06-2 19890301 Mar-01-1989 No None 1.3 x 10 -1 mg/kg-day None pesticide
104 Carbaryl 63-25-2 19911101 Nov-01-1991 Yes
Hepatic
Urinary
1 x 10 -1 mg/kg-day None pesticide
105 Carbofuran 1563-66-2 19870930 Sep-30-1987 Yes
Nervous
Reproductive
5 x 10 -3 mg/kg-day None pesticide
106 Carbon disulfide 75-15-0 19950801 Aug-01-1995 Yes
Developmental
Nervous
1 x 10 -1 mg/kg-day 7 x 10 -1 mg/m3 None
107 Carbon tetrachloride 56-23-5 20100331 Mar-31-2010 No Hepatic
4 x 10 -3 mg/kg-day 1 x 10 -1 mg/m3
Endocrine
Hepatic
108 Carbonyl sulfide 463-58-1 19911101 Nov-01-1991 Yes None None archive
109 Carbosulfan 55285-14-8 19870131 Jan-31-1987 Yes None 1 x 10 -2 mg/kg-day None
110 Carboxin 5234-68-4 19870131 Jan-31-1987 Yes None 1 x 10 -1 mg/kg-day None pesticide
111 Cerium Oxide and Cerium Compounds 1306-38-3 20090929 Sep-29-2009 No Respiratory
9 x 10 -4 mg/m3 None
112 Chloral hydrate 302-17-0 20000915 Sep-15-2000 Yes
Gastrointestinal
Nervous
1 x 10 -1 mg/kg-day None
113 Chloramben 133-90-4 19870131 Jan-31-1987 Yes Hepatic
1.5 x 10 -2 mg/kg-day None pesticide
114 Chlordane (Technical) 12789-03-6 19980207 Feb-07-1998 Yes Hepatic
5 x 10 -4 mg/kg-day 7 x 10 -4 mg/m3 Hepatic
pesticide
115 Chlordecone (Kepone) 143-50-0 20090922 Sep-22-2009 No Urinary
3 x 10 -4 mg/kg-day Hepatic
pesticide
116 Chlorimuron-ethyl 90982-32-4 19891101 Nov-01-1989 Yes Hematologic
2 x 10 -2 mg/kg-day None pesticide archive
117 Chlorine 7782-50-5 19940601 Jun-01-1994 Yes None 1 x 10 -1 mg/kg-day None
118 Chlorine cyanide 506-77-4 19870131 Jan-31-1987 No
Endocrine
Nervous
5 x 10 -2 mg/kg-day None
119 Chlorine dioxide 10049-04-4 20001011 Oct-11-2000 Yes
Cardiovascular
Developmental
Nervous
Respiratory
3 x 10 -2 mg/kg-day 2 x 10 -4 mg/m3 None
120 Chlorite (sodium salt) 7758-19-2 20001011 Oct-11-2000 No
Developmental
Nervous
3 x 10 -2 mg/kg-day None
121 1-Chloro-1,1-difluoroethane 75-68-3 19950701 Jul-01-1995 No None 5 x 10 1 mg/m3 None
122 2-Chloroacetophenone 532-27-4 19911001 Oct-01-1991 Yes Respiratory
3 x 10 -5 mg/m3 None
123 p-Chloroaniline 106-47-8 19880822 Aug-22-1988 Yes Immune
4 x 10 -3 mg/kg-day None
124 Chlorobenzene 108-90-7 19901101 Nov-01-1990 Yes Hepatic
2 x 10 -2 mg/kg-day None
125 Chlorobenzilate 510-15-6 19891201 Dec-01-1989 Yes Nervous
2 x 10 -2 mg/kg-day None
126 1-Chlorobutane 109-69-3 19900401 Apr-01-1990 No None None
127 2-Chlorobutane 78-86-4 19900401 Apr-01-1990 No None None
128 Chlorocyclopentadiene 41851-50-7 19900301 Mar-01-1990 No None None
129 Chlorodifluoromethane 75-45-6 19931101 Nov-01-1993 Yes
Endocrine
Urinary
5 x 10 1 mg/m3 None
130 Chloroform 67-66-3 20011019 Oct-19-2001 No Hepatic
1 x 10 -2 mg/kg-day Hepatic
131 Chloromethyl methyl ether (CMME) 107-30-2 19870930 Sep-30-1987 No None None
132 beta-Chloronaphthalene 91-58-7 19901101 Nov-01-1990 No
Hepatic
Respiratory
8 x 10 -2 mg/kg-day None
133 2-Chlorophenol 95-57-8 19880822 Aug-22-1988 Yes Reproductive
5 x 10 -3 mg/kg-day None
134 p-Chlorophenyl methyl sulfide 123-09-1 19930601 Jun-01-1993 No None None
135 p-Chlorophenyl methyl sulfone 98-57-7 19930601 Jun-01-1993 Yes None None
136 p-Chlorophenyl methyl sulfoxide 934-73-6 19930601 Jun-01-1993 Yes None None
137 Chloroprene 126-99-8 20100930 Sep-30-2010 No
Immune
Nervous
Respiratory
2 x 10 -2 mg/m3
Dermal
Gastrointestinal
Hepatic
Ocular
Reproductive
Respiratory
138 Chlorothalonil 1897-45-6 19880301 Mar-01-1988 No Urinary
1.5 x 10 -2 mg/kg-day None pesticide
139 o-Chlorotoluene 95-49-8 19900201 Feb-01-1990 Yes None 2 x 10 -2 mg/kg-day None
140 Chlorpropham 101-21-3 19980630 Jun-30-1998 Yes
Hematologic
Hepatic
Immune
Urinary
2 x 10 -1 mg/kg-day None pesticide archive
141 Chlorpyrifos 2921-88-2 20110324 Mar-24-2011 No None None pesticide archive
142 Chlorsulfuron 64902-72-3 19870131 Jan-31-1987 Yes None 5 x 10 -2 mg/kg-day None pesticide archive
143 Chromium(III), insoluble salts 16065-83-1 19980903 Sep-03-1998 Yes None 1.5 mg/kg-day None
144 Chromium(VI) 18540-29-9 20240801 Aug-01-2024 Yes
Developmental
Gastrointestinal
Hematologic
Hepatic
Respiratory
9 x 10 -4 mg/kg-day 3 x 10 -5 mg/m3
Gastrointestinal
Respiratory
145 Chrysene 218-01-9 19901201 Dec-01-1990 No None None
146 Cobalt and Cobalt Compounds 1307-96-6 No None None
147 Coke oven emissions None 19890501 May-01-1989 Yes