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List of Substances on IRIS

  • List A to Z
  • Assessments in Development
  • List by Archived

Assessments in Development

IRIS assessments in development for which draft materials have been released to the public, along with the current step in assessment development for each chemical. See the IRIS Process page for a description of each step, and the Quick Check on the chemical landing pages for a visualization of where each assessments is in the IRIS development process. Assessments in development are not included in the IRIS database and are not captured by IRIS Advanced Search. Use the table below to access these assessments.
An interactive version of this table is available.
Row Chemical Name CASRN IRIS Progress Step Draft Documents
1 Chloroform 67-66-3 Step 4
  • Dec 2024: IRIS Toxicological Review of Chloroform (Inhalation) (External Review Draft) (Report)

  • Mar 2024: IRIS Toxicological Review of Chloroform (Inhalation) (Interagency Science Consultation Draft, 2024) (Report)

  • Jan 2018: Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials) (Report)

  • Sep 2017: IRIS Assessment Plan for Chloroform (Scoping and Problem Formulation Materials) (Report)

  • Oct 2001: IRIS Toxicological Review of Chloroform (Final Report, 2001) (Report)

  • Apr 1988: Updated Health Effects Assessment for Chloroform (Report)

  • Sep 1984: Health Effects Assessment for Chloroform (Report)

2 Cobalt and Cobalt Compounds 1307-96-6 Step 3
  • Nov 2022: IRIS Assessment Plan and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds (Scoping and Problem Formulation Materials) (Report)

3 Ethylbenzene 100-41-4 Step 1
  • Feb 2023: Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

  • Sep 2017: IRIS Assessment Plan for Ethylbenzene (Scoping and Problem Formulation Materials) (Report)

  • Jul 2014: IRIS Toxicological Review of Ethylbenzene (Scoping and Problem Formulation Materials) (Report)

  • Mar 1985: Drinking Water Criteria Document For Ethylbenzene (Final Draft, 1985) (Report)

  • Sep 1984: Health Effects Assessment for Ethylbenzene (Report)

4 Manganese 7439-96-5 Step 1

No assessment materials are available.

5 Mercury Salts, Inorganic Various Step 1
  • Mar 2021: Systematic Review Protocol for the Inorganic Mercury Salts IRIS Assessment (Preliminary Assessment Materials) (Report)

  • Oct 2019: IRIS Assessment Plan for Inorganic Mercury Salts (Scoping and Problem Formulation Materials) (Report)

6 Methylmercury (MeHg) 22967-92-6 Step 1
  • May 2020: Systematic Review Protocol for the Methylmercury (MeHg) IRIS Assessment (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Assessment Plan for Methylmercury (Scoping and Problem Formulation Materials) (Report)

  • Jan 2001: IRIS Summary Update (2001) and EPA Guidelines for Methylmercury (2009 & 2010) (Other)

  • Oct 2000: Reference Dose for Methylmercury (External Review Draft, 2000) (Report)

7 Naphthalene 91-20-3 Step 1
  • Mar 2023: Protocol for the Naphthalene IRIS Assessment (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

  • Jul 2018: IRIS Assessment Plan for Naphthalene (2018, Scoping and Problem Formulation Materials) (Report)

  • Jul 2014: IRIS Toxicological Review of Naphthalene (2014, Scoping and Problem Formulation Materials) (Report)

  • Aug 2005: Research Needs Related to Naphthalene Assessment (2005, Workshop) (Report)

  • Sep 2004: Final Report from the External Peer Review of the IRIS Reassessment of the Inhalation Carcinogenicity of Naphthalene (2004) (Report)

  • Jul 2004: IRIS Toxicological Review of Naphthalene (2004, External Review Draft, Update) (Report)

  • May 2002: Summary Review of Health Effects Associated with Naphthalene: Health Issue Assessment (1987) (Report)

  • Aug 1998: IRIS Toxicological Review of Naphthalene (1998, Final) (Report)

  • Mar 1986: Health and Environmental Effects Profile for Naphthalene (1986) (Report)

  • Sep 1984: Health Effects Assessment for Naphthalene (Report)

8 Nitrate 14797-55-8 Step 1
  • Nov 2023: Protocol for the Nitrate and Nitrite IRIS Assessment (Oral) (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

  • Sep 2017: IRIS Assessment Plan for Nitrate and Nitrite (Scoping and Problem Formulation Materials, 2017) (Report)

9 Nitrite 14797-65-0 Step 1
  • Nov 2023: Protocol for the Nitrate and Nitrite IRIS Assessment (Oral) (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

  • Sep 2017: IRIS Assessment Plan for Nitrate and Nitrite (Scoping and Problem Formulation Materials, 2017) (Report)

10 Perfluorononanoic Acid (PFNA) 375-95-1 Step 6
  • Jul 2024: External Peer Review Activities for PFNA Integrated Risk Information System (IRIS) Assessment (July/August 2024) (Other)

  • May 2024: IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Public Comment and External Review Draft) (Report)

  • Jul 2023: IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Interagency Science Consultation Draft, 2023) (Report)

  • Nov 2019: Systematic Review Protocol for the Perfluorononanoic Acid (PFNA) IRIS Assessment (Preliminary Assessment Materials) (Report)

11 Polychlorinated Biphenyls (PCBs) 1336-36-3 Step 1
  • Mar 2023: A Systematic Evidence Map of Noncancer Health Endpoints and Exposures to Polychlorinated Biphenyl (PCB) Mixtures (Report)

  • Mar 2022: Mixtures Modeling Methods: Applications for Assessing Polychlorinated Biphenyls (PCBS) (Webinar) (Other)

  • Dec 2019: Systematic Review Protocol for the Polychlorinated Biphenyls (PCBs) Noncancer IRIS Assessment (Preliminary Assessment Materials) (Report)

  • Mar 2015: IRIS Toxicological Review of Polychlorinated Biphenyls (PCBs) (Scoping and Problem Formulation Materials) (Report)

  • Sep 1996: PCBs: Cancer Dose-Response Assessment and Application to Environmental Mixtures (1996) (Report)

  • Sep 1984: Health Effects Assessment for Polychlorinated Biphenyls (PCBs) (Report)

12 Uranium, natural 7440-61-1 Step 1
  • Feb 2024: Protocol for the Uranium IRIS Assessment (Oral) (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

  • Jan 2018: IRIS Assessment Plan for Uranium (Scoping and Problem Formulation Materials) (Report)

13 Vanadium and Compounds (Oral) Various Step 1
  • Apr 2021: Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials) (Report)

  • Jul 2020: IRIS Assessment Plan for Oral Exposure to Vanadium and Compounds (Scoping and Problem Formulation Materials) (Report)

14 Vanadium and Compounds (Inhalation) Various Step 1
  • Aug 2023: Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials) (Report)

  • May 2021: IRIS Assessment Plan for Inhalation Exposure to Vanadium and Compounds (Scoping and Problem Formulation Materials) (Report)

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