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List of Substances on IRIS

  • List A to Z
  • Assessments in Development
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Assessments in Development

IRIS assessments in development for which draft materials have been released to the public, along with the current step in assessment development for each chemical. See the IRIS Process page for a description of each step, and the Quick Check on the chemical landing pages for a visualization of where each assessments is in the IRIS development process. Assessments in development are not included in the IRIS database and are not captured by IRIS Advanced Search. Use the table below to access these assessments.
A basic version of this table is available.
Row Chemical Name CASRN IRIS Progress Step Draft Documents
1 Chloroform 67-66-3 Step 4
  • Dec 2024: IRIS Toxicological Review of Chloroform (Inhalation) (External Review Draft) (Report)

  • Jan 2018: Systematic Review Protocol For The IRIS Chloroform Assessment (Inhalation) (Preliminary Assessment Materials) (Report)

2 Cobalt and Cobalt Compounds 1307-96-6 Step 3
  • Nov 2022: IRIS Assessment Plan and Protocol for Assessing Cancer Risk from Inhalation Exposure to Cobalt and Cobalt Compounds (Scoping and Problem Formulation Materials) (Report)

3 Ethylbenzene 100-41-4 Step 1
  • Feb 2023: Protocol for the Ethylbenzene IRIS Assessment (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

  • Mar 1985: Drinking Water Criteria Document For Ethylbenzene (Final Draft, 1985) (Report)

4 Manganese 7439-96-5 Step 1

No assessment materials are available.

5 Mercury Salts, Inorganic Various Step 1
  • Mar 2021: Systematic Review Protocol for the Inorganic Mercury Salts IRIS Assessment (Preliminary Assessment Materials) (Report)

6 Methylmercury (MeHg) 22967-92-6 Step 1
  • May 2020: Systematic Review Protocol for the Methylmercury (MeHg) IRIS Assessment (Preliminary Assessment Materials) (Report)

7 Naphthalene 91-20-3 Step 1
  • Mar 2023: Protocol for the Naphthalene IRIS Assessment (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

8 Nitrate 14797-55-8 Step 1
  • Nov 2023: Protocol for the Nitrate and Nitrite IRIS Assessment (Oral) (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

9 Nitrite 14797-65-0 Step 1
  • Nov 2023: Protocol for the Nitrate and Nitrite IRIS Assessment (Oral) (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

10 Perfluorononanoic Acid (PFNA) 375-95-1 Step 6
  • Jul 2024: External Peer Review Activities for PFNA Integrated Risk Information System (IRIS) Assessment (July/August 2024) (Other)

  • May 2024: IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Public Comment and External Review Draft) (Report)

  • Jul 2023: IRIS Toxicological Review of Perfluorononanoic Acid (PFNA) and Related Salts (Interagency Science Consultation Draft, 2023) (Report)

  • Nov 2019: Systematic Review Protocol for the Perfluorononanoic Acid (PFNA) IRIS Assessment (Preliminary Assessment Materials) (Report)

11 Polychlorinated Biphenyls (PCBs) 1336-36-3 Step 1
  • Mar 2023: A Systematic Evidence Map of Noncancer Health Endpoints and Exposures to Polychlorinated Biphenyl (PCB) Mixtures (Report)

  • Dec 2019: Systematic Review Protocol for the Polychlorinated Biphenyls (PCBs) Noncancer IRIS Assessment (Preliminary Assessment Materials) (Report)

12 Uranium, natural 7440-61-1 Step 1
  • Feb 2024: Protocol for the Uranium IRIS Assessment (Oral) (Preliminary Assessment Materials) (Report)

  • Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

13 Vanadium and Compounds (Oral) Various Step 1
  • Apr 2021: Systematic Review Protocol for the Vanadium and Compounds (Oral Exposure) IRIS Assessment (Preliminary Assessment Materials) (Report)

14 Vanadium and Compounds (Inhalation) Various Step 1
  • Aug 2023: Protocol for the Vanadium and Compounds (Inhalation) IRIS Assessment (Preliminary Assessment Materials) (Report)

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