Di (2-ethylhexyl)phthalate (DEHP)
CASRN 117-81-7 | DTXSID5020607
- IRIS Summary (PDF) (14 pp, 121 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 121 K) Last Updated: 01/31/1987
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 2 x 10 -2 | Increased relative liver weight |
LOAEL
:
1.9
x 101
mg/kg-day |
1000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 121 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(14 pp, 121 K)
Last Updated: 09/07/1988
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Orally administered DEHP produced significant dose-related increases in liver tumor responses in rats and mice of both sexes.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 121 K)
Oral Slope Factor:
1.4
x 10-2
per mg/kg-day
Drinking Water Unit Risk:
4
x 10-7
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma and adenoma (NTP, 1982)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 121 K)
Not Assessed under the IRIS Program.
Chemical Documents
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
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- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Related Links
Critical Effects
Tumor Sites
Chemical Structure
Synonyms
- BEHP
- Bis(2-ethylhexyl)-1,2-benzene-dicarboxylate
- Bis(2-ethylhexyl)phthalate
- Bisoflex 81
- Bisoflex DOP
- Compound 889
- DAF 68
- DEHP
- DOP
- Di(2-ethylhexyl)orthophthalate
- Di(2-ethylhexyl)phthalate
- Di(2-ethylhexyl)phthalate (DEHP)
- Di-sec-octyl phthalate
- Dioctyl phthalate
- Ergoplast FDO
- Ethylhexyl phthalate
- Eviplast 80
- Eviplast 81
- Fleximel
- Flexol DOP
- Flexol Plasticizer DOP
- Good-Rite GP 264
- Hatcol DOP
- Hercoflex 260
- Kodaflex DOP
- Mollan O
- NCI- C52733
- Nuoplaz DOP
- Octoil
- Octyl phthalate
- Palatinol AH
- Phthalic acid, bis(2-ethylhexyl) ester
- Phthalic acid, dioctyl ester
- Pittsburgh PX-138
- Platinol DOP
- RC Plasticizer DOP
- RCRA Waste Number u028
- Reomol D 79P
- Reomol DOP
- Sicol 150
- Staflex DOP
- Truflex DOP
- Vestinol AH
- Vinicizer 80
- Witcizer 312
- 117-81-7
- 2-Ethylhexyl phthalate