Methyl methacrylate

CASRN 80-62-6 | DTXSID2020844

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Other	1.4	None	NOAEL : 1.36 x 10² mg/kg-day	100	Low/Medium

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous, Respiratory	7 x 10 ^-1	Degeneration/ atrophy of olfactory epithelium (male rats)	BMC ₁₀ (HEC): 7.2 mg/m³	10	Medium/High

Weight of Evidence for Cancer (PDF) (31 pp, 204 K) Last Updated: 03/02/1998

WOE Characterization	Framework for WOE Characterization
E (Evidence of non-carcinogenicity for humans)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Not likely to be carcinogenic to humans	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

Under EPA's 1986 Guidelines for Carcinogen Risk Assessment, MMA would be classified as evidence of non-carcinogenicity for humans or a Group E chemical. Under the Proposed Guidelines for Carcinogenic Risk Assessment (U.S. EPA, 1996), MMA is considered not likely to be carcinogenic to humans by any route of exposure because it has been evaluated in four well-conducted chronic inhalation studies in three appropriate animal species without demonstrating carcinogenic effects.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.