2-Hexanone

CASRN 591-78-6 | DTXSID0022068

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Nervous	5 x 10 ^-3	Axonal swelling of the peripheral nerve	BMDL ₁₀ : 5 mg/kg-day	1000	Medium

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous	3 x 10 ^-2	Motor conduction velocity of the sciatic-tibial nerve	BMCL ₀₅ (HEC): 90 mg/m³	3000	Low

Weight of Evidence for Cancer (PDF) (19 pp, 148 K) Last Updated: 09/25/2009

WOE Characterization	Framework for WOE Characterization
Inadequate information to assess carcinogenic potential	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for 2-hexanone is "inadequate to assess human carcinogenic potential."
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.