Toluene

CASRN 108-88-3 | DTXSID7021360

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Urinary	8 x 10 ^-2	Increased kidney weight	BMDL : 238 mg/kg-day	3000	Medium

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous	5	Neurological effects in occupationally-exposed workers	NOAEL (ADJ): 46 mg/m³	10	High

Weight of Evidence for Cancer (PDF) (35 pp, 230 K) Last Updated: 09/23/2005

WOE Characterization	Framework for WOE Characterization
Inadequate information to assess carcinogenic potential	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), there is inadequate information to assess the carcinogenic potential of toluene because studies of humans chronically exposed to toluene are inconclusive, toluene was not carcinogenic in adequate inhalation cancer bioassays of rats and mice exposed for life (CIIT, 1980 NTP, 1990 Huff, 2003), and increased incidences of mammary cancer and leukemia were reported in a lifetime rat oral bioassay at a dose level of 500 mg/kg-day but not at 800 mg/kg-day (Maltoni et al., 1997).
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.