Cumene

CASRN 98-82-8 | DTXSID1021827

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Urinary	1 x 10 ^-1	Increased average kidney weight in female rats	NOAEL : 1.10 x 10² mg/kg-day	1000	Low

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Endocrine, Urinary	4 x 10 ^-1	Increased kidney weights in female rats and adrenal weights in male and female rats	NOAEL (HEC): 4.35 x 10² mg/m³	1000	Medium

Weight of Evidence for Cancer (PDF) (22 pp, 155 K) Last Updated: 08/01/1997

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Carcinogenic potential cannot be determined	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

Under the proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), it is concluded that the carcinogenic potential of cumene cannot be determined because no adequate data, such as well-conducted long-term animal studies or reliable human epidemiological studies, are available for any assessment.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.