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trans-1,2-Dichloroethylene

CASRN 156-60-5 | DTXSID7024031

  • Toxicological Review (PDF) (174 pp, 1.18 M)
  • IRIS Summary (PDF) (22 pp, 215 K)

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (22 pp, 215 K) Last Updated: 09/30/2010

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Immune 2 x 10 -2 Decrease in number of antibody forming cells (AFCs) against sheep red blood cells (sRBCs) in male mice BMDL 1SD : 65.0
mg/kg-day
3000 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (22 pp, 215 K) Last Updated: 09/30/2010

Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (22 pp, 215 K) Last Updated: 09/30/2010

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), there is "inadequate information to assess the carcinogenic potential" of trans-1,2-DCE.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (22 pp, 215 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (22 pp, 215 K)

Not assessed under the IRIS Program.

Chemical Documents

Sep 2010: IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (Final Report) (Report)

Jul 2010: IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Discussion Draft) (Report)

Sep 2009: IRIS Toxicological Review of Cis-& Trans-1,2-Dichloroethylene (External Review Draft) (Report)

Aug 2009: IRIS Toxicological Review of cis- & trans-1,2-Dichloroethylene (Interagency Science Consultation Draft) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - trans-1,2-Dichloroethylene
  • cis-1,2-Dichloroethylene
  • eChemPortal - Dichloroethylene

Critical Effects

Immune
Immune

Chemical Structure

trans-1,2-Dichloroethylene

Synonyms

  • Acetylene dichloride, trans-
  • Dichloroethylene, trans-
  • Ethylene, 1,2-dichloro-, (E)-
  • RCRA Waste Number u079
  • trans-1,2-Dichloroethylene
  • trans-Acetylene dichloride
  • trans-Dichloroethylene
  • 1,2-Dichloroethylene, trans-
  • 156-60-5
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