Acrolein

CASRN 107-02-8 | DTXSID5020023

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Other	5 x 10 ^-4	Decreased survival	NOAEL : 0.05 mg/kg-day	100	Medium/High

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Respiratory	2 x 10 ^-5	Nasal lesions	LOAEL (HEC): 0.02 mg/m³	1000	Medium

Weight of Evidence for Cancer (PDF) (25 pp, 176 K) Last Updated: 06/03/2003

WOE Characterization	Framework for WOE Characterization
Data are inadequate for an assessment of human carcinogenic potential	Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999)

Basis:

Under the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), the potential carcinogenicity of acrolein cannot be determined because the existing data are inadequate for an assessment of human carcinogenic potential for either the oral or inhalation route of exposure. There are no adequate human studies of the carcinogenic potential of acrolein. Collectively, experimental studies provide inadequate evidence that acrolein causes cancer in laboratory animals.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.