Bis(chloromethyl)ether (BCME)
CASRN 542-88-1 | DTXSID8020173
- IRIS Summary (PDF) (12 pp, 113 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 113 K) Last Updated:
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 113 K) Last Updated: 07/01/1991
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(12 pp, 113 K)
Last Updated: 09/26/1988
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| A (Human carcinogen) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Statistically significant increases in lung tumors (oat cell carcinomas) observed in six studies of exposed workers and bioassay data from rats and mice.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 113 K)
Oral Slope Factor:
2.2
x 102
per mg/kg-day
Drinking Water Unit Risk:
6.2
x 10-3
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Respiratory tract tumors (Kuschner et al., 1975)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 113 K)
Inhalation Unit Risk:
6.2
x 10-2
per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Respiratory tract tumors (Kuschner et al., 1975)
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Related Links
Tumor Sites
Chemical Structure
Synonyms
- BCME
- Bis(chloromethyl)ether
- Bis(chloromethyl)ether (BCME)
- Bis-CME
- Chloro(chloromethoxy)methane
- Chloromethyl ether
- Dichlordimethylaether
- Dimethyl-1,1'-dichloroether
- Ether, bis(chloromethyl)
- Methane, oxybis(chloro-
- Oxybis(chloromethane)
- RCRA Waste Number p016
- UN 2249
- sym-Dichloro-dimethyl ether
- sym-Dichloromethyl ether
- 1,1'-Dichlorodimethyl ether
- 542-88-1