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4,4'-Methylene bis(N,N'-dimethyl)aniline

CASRN 101-61-1 | DTXSID5020869

  • IRIS Summary (PDF) (10 pp, 104 K)

On this page:

  • Key IRIS
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (10 pp, 104 K) Last Updated:

Not assessed under the IRIS Program.


Reference Concentration for Inhalation Exposure (RfC) (PDF) (10 pp, 104 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (10 pp, 104 K) Last Updated: 08/01/1989

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Sufficient evidence from animal experiments: thyroid tumors in male and female rats, and liver carcinoma/adenoma in the female mice with a significant positive trend in male mice. There is evidence of mutagenic activity. There are no human data.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (10 pp, 104 K)

Oral Slope Factor: 4.6 x 10-2 per mg/kg-day
Drinking Water Unit Risk: 1.3 x 10-6 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Endocrine
Tumor type(s): Thyroid, follicular cell carcinoma/ adenoma (NCI, 1979a)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (10 pp, 104 K)

Not Assessed under the IRIS Program.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - 4,4'-Methylene bis(N,N'-dimethyl)aniline
  • eChemPortal - Methylene bis(N,N'-dimethyl)aniline

Tumor Sites

Endocrine
Endocrine

Chemical Structure

4,4'-Methylene bis(N,N'-dimethyl)aniline

Synonyms

  • Aniline, 4,4'-methylenebis(n,n-dimethyl-
  • Baze michlerova (Czech)
  • Benzenamine, 4-4'-methylenebis(n,n-dimethyl)-
  • Diphenylmethane, tetramethyldiamino-
  • Methane Base
  • Methane, bis(p-(dimethylamino)phenyl)-
  • Methylene base
  • Methylene bis (N,N'-dimethyl) aniline
  • Michler's Base
  • Michler's Hydride
  • Michler's Methane
  • NCI-C1990
  • Reduced Michler's Ketone
  • Tetra-base
  • Tetramethyldiaminodiphenylmethane
  • bis(4-(Dimethylamino)phenyl)methane
  • bis(4-(n,n-Dimethylamino)phenyl)methane
  • bis(p-(n,n-Dimethylamino)phenyl)methane
  • bis(p-Dimethylaminophenyl)methane
  • n,n,n'n'-Tetramethyl-4,4'-diaminodiphenylmethane
  • n,n,n'n'-Tetramethyl-p,p'-diaminodiphenylmethane
  • p,p'-bis(Dimethylamino)diphenylmethane
  • p,p'-bis(n,n-Dimethylaminophenyl)methane
  • p,p-Dimethylaminodiphenylmethane
  • p,p-Tetramethyldiaminodiphenylmethane
  • 101-61-1
  • 4,4'-Methylenebis(n,n-dimethyl)benzenamine
  • 4,4'-Methylenebis(n,n-dimethylaniline)
  • 4,4'-bis(Dimethylamino)diphenylmethane
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