Crotonaldehyde

Reference Dose for Oral Exposure (RfD) (PDF) (8 pp, 101 K) Last Updated:

Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (8 pp, 101 K)

Not assessed under the IRIS Program.

Weight of Evidence for Cancer (PDF) (8 pp, 101 K) Last Updated: 06/01/1991

• Based on no human data and an increased incidence of hepatocellular carcinomas and hepatic neoplastic nodules (combined) in male F344 rats. The possible carcinogenicity of crotonaldehyde is supported by genotoxic activity and the expected reactivity of croton oil and aldehyde. Crotonaldehyde is also a suspected metabolite of N-nitrosopyrrolidine, a probable human carcinogen.
• This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (8 pp, 101 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (8 pp, 101 K)

Not assessed under the IRIS Program.