Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI)
CASRN 101-68-8 | DTXSID7025180
- Toxicological Review (PDF) (54 pp, 154 K)
- IRIS Summary (PDF) (23 pp, 170 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 170 K) Last Updated:
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF) (23 pp, 170 K) Last Updated: 02/07/1998
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous, Respiratory | 6 x 10 -4 | Hyperplasia of olfactory epithelium |
BMC
10
(HEC):
6
x 10-2 mg/m3 |
100 | Medium |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(23 pp, 170 K)
Last Updated: 02/07/1998
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
| Carcinogenic potential cannot be determined | Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996) |
- Under U.S. EPA's 1996 Proposed Guidelines for Carcinogen Risk Assessment, the carcinogenic potential of MDI/PMDI would be characterized as "cannot be determined," but for which there is suggestive evidence that raises concern for carcinogenic effects.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (23 pp, 170 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (23 pp, 170 K)
Not assessed under the IRIS Program.
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Related Links
Critical Effects
Chemical Structure
Synonyms
- Benzene, 1,1' -methylenebis(4-isocyanato-
- Caradate 30
- Desmodur 44
- Difenil-methan-diisocianato (Italian)
- Difenylmethaan-dissocyanaat (Dutch)
- Diisocyanate de diophenylmethane-4,4' (french)
- Diphenyl methane diisocyanate
- Diphenylmethan-4,4' -diisocyanat (German)
- Diphenylmethane 4,4' -diisocyanate
- Diphenylmethane diisocyanate
- Diphenylmethane-4,4' -diisocyanate
- HSDB 2630
- Hylene m50
- Isocyanic acid < methylenedi-p-phenylene ester
- Isonate 125 mf
- Isonate 125m
- MDI
- Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeri MDI (PMDI)
- Methylene di (phenylene isocyanate)
- Methylenebis (4-isocyanatobenene)
- Methylenebis (4-phenyl isocyanate)
- Methylenebis (4-phenylene isocyanate)
- Methylenebis (4-phenylisocyanate)
- Methylenebis (p-phenyl isocyanate)
- Methylenebis (p-phenylene isocyanate)
- Methylenedi-p-phenylene diisocyanate
- Methylenedi-p-phenylene isocyanate
- NCI-C50668
- NSC 9596
- Nacconate 300
- UN 2489
- bis (1,4-Isocyanathophenyl) methane
- bis (4-Isocyanatophenyl) methane
- bis (p-Isocyanatophenyl) methane
- di-(4-Isocyanatophenyl) methane
- p,p' -Dipohenylmethane diisocyanate
- p,p' -Methylenebis (phenyl isocyanate)
- 1,1' - Methylenebis (4-isocyanatobenzene)
- 101-68-8
- 4,4' - Diisocianato de difenilmetano (Spanish)
- 4,4' - Diisocyanate de diphenylmethane (French)
- 4,4' - Diisocyanathodiphenylmethane
- 4,4' - Diphenylmethane dilsocyanate
- 4,4' - Methylenebis (phenyl isocyanate)
- 4,4' - Methylenedi - p- phenylene diisocyanate
- 4,4' - Methylenediphenyl diisocyanate
- 4,4' - Methylenediphenylene isocyanate
- 9016-87-9