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Dichloroacetic acid

CASRN 79-43-6 | DTXSID2020428

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Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (40 pp, 324 K) Last Updated: 09/11/2003

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous, Reproductive, Hepatic 4 x 10 -3 Lesions observed in the testes, cerebrum, cerebellum, and liver. LOAEL : 12.5
mg/kg-day 		3000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (40 pp, 324 K) Last Updated: 09/11/2003

Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (40 pp, 324 K) Last Updated: 09/11/2003

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999)
Basis:
  • EPA believes that DCA is likely to be a carcinogen in humans.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (40 pp, 324 K)

Oral Slope Factor: 5 x 10-2 per mg/kg-day
Drinking Water Unit Risk: 1.4 x 10-6 per µg/L
Extrapolation Method: Multistage model with Benchmark Dose Modeling
Tumor site(s): Hepatic
Tumor type(s): Hepatoadenoma and Hepatocarcinoma (DeAngelo et. al., 1999)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (40 pp, 324 K)

Information reviewed but value not estimated.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:

Related Links

Critical Effects

Hepatic
Hepatic

Nervous
Nervous

Reproductive
Reproductive

Tumor Sites

Hepatic
Hepatic

Chemical Structure

Dichloroacetic acid

Synonyms

  • AI3-18370
  • Acetic acid, dichloro-
  • Acide dichloracetique [French]
  • Acido dicloroacetico [Spanish]
  • Dichlorethanoic acid
  • Dichloroacetic acid
  • Kyselina dichloroctova [Czech]
  • 79-43-6
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