Trichloroacetic acid
CASRN 76-03-9 | DTXSID1021378
- Toxicological Review (PDF) (270 pp, 2.08 M)
- IRIS Summary (PDF) (26 pp, 273 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (26 pp, 273 K) Last Updated: 09/30/2011
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 2 x 10 -2 | Hepatocellular necrosis |
BMDL
10
:
18
mg/kg-day |
1000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (26 pp, 273 K) Last Updated: 09/30/2011
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(26 pp, 273 K)
Last Updated: 09/30/2011
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Suggestive evidence of carcinogenic potential | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (Cancer Guidelines) (U.S. EPA, 2005a), there is suggestive evidence of carcinogenic potential for TCA based on significantly increased incidences of liver tumors in male B6C3F1 mice exposed via drinking water for 52–104 weeks (DeAngelo et al., 2008 Bull et al., 2002, 1990 Herren-Freund et al., 1987) and female B6C3F1 mice exposed for 51 or 82 weeks (Pereira, 1996), and lack of treatment-related tumors in a study of male F344/N rats following lifetime exposure in drinking water (DeAngelo et al., 1997).
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (26 pp, 273 K)
Oral Slope Factor:
7
x 10-2
per mg/kg-day
Drinking Water Unit Risk:
2
x 10-6
per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the POD (LED10).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (DeAngelo et al. (2008))
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (26 pp, 273 K)
Information reviewed but value not estimated.
Chemical Documents
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Critical Effects
Tumor Sites
Chemical Structure
Synonyms
- AI3-24157
- Acetic acid, trichloro-
- Aceto-Caustin
- Acide trichloracetique [French]
- Acido tricloroacetico [Italian]
- Acido tricloroacetico [Spanish]
- Amchem Grass Killer
- Caswell No. 870
- EPA Pesticide Chemical Code 081002
- HSDB 1779
- Kyselina trichloroctova [Czech]
- TCA
- Trichloorazijnzuur [Dutch]
- Trichloressigsaeure [German]
- Trichloroacetic acid
- Trichloroethanoic acid
- 76-03-9