Methyl ethyl ketone (MEK)

CASRN 78-93-3 | DTXSID3021516

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Developmental	6 x 10 ^-1	Decreased pup body weight	LED ₅ : 639 mg/kg-day	1000	Low

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Developmental, Musculoskeletal	5	Developmental toxicity (skeletal variations)	LEC (HEC): 1517 mg/m³	300	Medium

Weight of Evidence for Cancer (PDF) (33 pp, 211 K) Last Updated: 09/26/2003

WOE Characterization	Framework for WOE Characterization
Data are inadequate for an assessment of human carcinogenic potential	Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999)

Basis:

Under the draft revised guidelines for carcinogen risk assessment (U.S. EPA, 1999), EPA concludes the data are inadequate for an assessment of human carcinogenic potential of MEK. Studies of humans chronically exposed to MEK are inconclusive, and MEK has not been tested for carcinogenicity in animals by the oral or inhalation routes.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.