Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock ( Lock A locked padlock ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

  • Environmental Topics
  • Laws & Regulations
  • Report a Violation
  • About EPA
IRIS
Contact Us

Nitrate

CASRN 14797-55-8 | DTXSID5024217

  • IRIS Summary (PDF) (12 pp, 106 K)
  • Status: Nitrate is in step 1 at this time; see Quick Check.

On this page:

  • Key IRIS
    Values
  • Assessment
    Status
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 106 K) Last Updated: 05/01/1991

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hematologic 1.6 Early clinical signs of methemoglobinemia in excess of 10% (0-3 months old infants formula) NOAEL : 1.6
mg/kg-day
1 High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 106 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (12 pp, 106 K)
Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 106 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 106 K)

Not assessed under the IRIS Program.

Program Outlook Details

Public Assessment Materials Date
Problem Formulation Materials/IRIS Assessment Plan Sep-2017
Preliminary Assessment Materials/Systematic Review Protocol Oct-2023
Public Comment TBD
External Peer Review TBD
Post Final Assessment TBD

Note: Any future dates displayed in the table above should be considered estimates and are subject to change. Once the external peer review is complete, estimated dates for release of the final assessment will be published. For the latest information on the status of this assessment, please refer to the IRIS Program Outlook. To access assessment documents, meeting materials or other supporting documents related to this assessment, see the list of Chemical Documents. For more information about the development process, visit the IRIS Process page.

Chemical Documents

Nov 2023: Protocol for the Nitrate and Nitrite IRIS Assessment (Oral) (Preliminary Assessment Materials) (Report)

Apr 2019: IRIS Program Outlook April 2019-Suspended/Discontinued Assessment (Other)

Sep 2017: IRIS Assessment Plan for Nitrate and Nitrite (Scoping and Problem Formulation Materials, 2017) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Quick Check

Image text: 1. (highlighted) Draft Development, 2. Agency Review, 3. Interagency Science Consultation, 4. Public Comment and External Peer Review, 5. Revise Assessment, 6. Final Agency Review/Interagency Science Discussion, 7. Final Assessment

Related Links

  • EPA Chemicals Dashboard - Nitrate
  • Nitrite

Critical Effects

Hematologic
Hematologic

Chemical Structure

Nitrate

Synonyms

  • Nitrate
  • Nitric acid, ion(1-)
  • 14797-55-8
  • IRIS Home
  • About IRIS
  • IRIS Recent Additions
  • IRIS Calendar
  • IRIS Assessments
  • Advanced Search
  • IRIS Program Materials
Contact Us to ask a question, provide feedback, or report a problem.
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshots
  • Grants
  • No FEAR Act Data
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data.gov
  • Inspector General
  • Jobs
  • Newsroom
  • Open Government
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions

Follow.