Bromate CASRN 15541-45-4 | IRIS

IRIS

Bromate

CASRN 15541-45-4 | DTXSID8023923

Toxicological Review (PDF) (58 pp, 261 K)
IRIS Summary (PDF) (27 pp, 186 K)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (27 pp, 186 K) Last Updated: 06/06/2001

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Urinary	4 x 10 ^-3	Renal effects: urothelial hyperplasia	NOAEL : 1.1 mg/kg-day	300	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (27 pp, 186 K) Last Updated: 06/06/2001
Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (27 pp, 186 K) Last Updated: 06/06/2001

WOE Characterization	Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Carcinogenic potential cannot be determined (Inhalation route)	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)
Known/likely human carcinogen (Oral route)	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

Under the current Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986), bromate would be classified as B2, probable human carcinogen. Under the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), bromate should be evaluated as a likely human carcinogen by the oral route of exposure. Insufficient data are available to evaluate the human carcinogenic potential of bromate by the inhalation route.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 186 K)

Oral Slope Factor: 7 x 10^-1 per mg/kg-day
Drinking Water Unit Risk: 2 x 10^-5 per µg/L
Extrapolation Method: Time-to-tumor, Weibull
Tumor site(s): Urinary, Reproductive, Endocrine
Tumor type(s): Testicular mesothelioma, renal tubular adenoma and carcinoma, and thyroid follicular cell adenoma and carcinoma (DeAngelo et al., 1998)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 186 K)

Information reviewed but value not estimated.

Mar 2012: Dose-Response Analysis Of Bromate-Induced Dna Damage And Mutagenicity Is Consistent With Low-Dose Linear, Non-Threshold Processes (Journal)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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