Methyl chloride
CASRN 74-87-3 | DTXSID0021541
- Toxicological Review (PDF) (95 pp, 337 K)
- IRIS Summary (PDF) (23 pp, 165 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 165 K) Last Updated: 07/17/2001
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF) (23 pp, 165 K) Last Updated: 07/17/2001
System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
---|---|---|---|---|---|
Nervous | 9 x 10 -2 | Cerebellar lesions |
NOAEL
(HEC):
9.46
x 101 mg/m3 |
1000 | Medium |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(23 pp, 165 K)
Last Updated: 07/17/2001
WOE Characterization | Framework for WOE Characterization |
---|---|
D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
Carcinogenic potential cannot be determined | Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996) |
- Applying the criteria for evaluating the overall weight-of-evidence for carcinogenicity to humans outlined in EPA's guidelines for carcinogen risk assessment (U.S. EPA, 1986), methyl chloride is most appropriately designated a Group D - Not classifiable as to its human carcinogenicity. Using the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), the available data suggest that methyl chloride would be classified as an agent whose carcinogenic potential cannot be determined.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (23 pp, 165 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (23 pp, 165 K)
Not assessed under the IRIS Program.
Chemical Documents
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Critical Effects
Chemical Structure
Synonyms
- Chloromethane
- Methyl chloride
- Monochloromethane
- 74-87-3