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Methyl chloride

CASRN 74-87-3 | DTXSID0021541

  • Toxicological Review (PDF) (95 pp, 337 K)
  • IRIS Summary (PDF) (23 pp, 165 K)

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 165 K) Last Updated: 07/17/2001

Not assessed under the IRIS Program.


Reference Concentration for Inhalation Exposure (RfC) (PDF) (23 pp, 165 K) Last Updated: 07/17/2001

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous 9 x 10 -2 Cerebellar lesions NOAEL (HEC): 9.46 x 101
mg/m3
1000 Medium

Cancer Assessment

Weight of Evidence for Cancer (PDF) (23 pp, 165 K) Last Updated: 07/17/2001

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Carcinogenic potential cannot be determined Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)
Basis:
  • Applying the criteria for evaluating the overall weight-of-evidence for carcinogenicity to humans outlined in EPA's guidelines for carcinogen risk assessment (U.S. EPA, 1986), methyl chloride is most appropriately designated a Group D - Not classifiable as to its human carcinogenicity. Using the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), the available data suggest that methyl chloride would be classified as an agent whose carcinogenic potential cannot be determined.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (23 pp, 165 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (23 pp, 165 K)

Not assessed under the IRIS Program.

Chemical Documents

Jul 2000: Toxicological Review of Methyl Chloride and IRIS Summary (External Peer Review Draft) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Methyl chloride
  • eChemPortal - Methyl chloride

Critical Effects

Nervous
Nervous

Chemical Structure

Methyl chloride

Synonyms

  • Chloromethane
  • Methyl chloride
  • Monochloromethane
  • 74-87-3
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