Perchlorate (ClO4) and Perchlorate Salts

CASRN 7790-98-9 | DTXSID4024515

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Endocrine	7 x 10 ^-4	Radioactive iodide uptake inhibition (RAIU) in the thyroid	NOEL : 7 x 10^-3 mg/kg-day	10	High

Information reviewed but value not estimated.

Weight of Evidence for Cancer (PDF) (22 pp, 157 K) Last Updated: 02/18/2005

WOE Characterization	Framework for WOE Characterization
Not likely to be carcinogenic to humans	Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999)

Basis:

Under U.S. EPAs 1999 Draft Revised Guidelines for Carcinogen Risk Assessment, perchlorate is not likely to pose a risk of thyroid cancer in humans, at least at doses below those necessary to alter thyroid hormone homeostasis, based on the hormonally-mediated mode of action in rodent studies and species differences in thyroid function.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.