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2,2',4,4'-Tetrabromodiphenyl ether (BDE-47)

CASRN 5436-43-1 | DTXSID3030056

  • Toxicological Review (PDF) (85 pp, 380 K)
  • IRIS Summary (PDF) (14 pp, 128 K)

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 128 K) Last Updated: 06/30/2008

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous 1 x 10 -4 Neurobehavioral effects BMDL (1SD): 0.35
mg/kg
3000 Low

Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 128 K) Last Updated: 06/30/2008

Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (14 pp, 128 K) Last Updated: 06/30/2008

WOE Characterization Framework for WOE Characterization
Inadequate information to assess carcinogenic potential Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), there is "inadequate information to assess the carcinogenic potential" of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47).
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 128 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 128 K)

Not assessed under the IRIS Program.

Chemical Documents

Jun 2008: IRIS Health Assessment Of 2,2',4,4'-Tetrabromodiphenyl Ether (BDE-47) CASRN 5436-43-12,2',4,4',5-Pentabromodiphenyl Ether (BDE-99) CASRN 60348-60-92,2',4,4',5,5'-Hexabromodiphenyl Ether (BDE-153) CASRN 68631-49-22,2',3,3',4,4',5,5',6,6'-Decabromodiphenyl Ether (BDE-209) CASRN 1163-19-5 (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47)
  • eChemPortal - Tetrabromodiphenyl ether (BDE-47)

Critical Effects

Nervous
Nervous

Chemical Structure

2,2',4,4'-Tetrabromodiphenyl ether (BDE-47)

Synonyms

  • BDE-47
  • Benzene, 1,1'-oxybis(2,4-dibromo)-
  • PBDE 47
  • 2,2',4,4'-Tetrabromodiphenyl ether
  • 5436-43-1
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