Tetrahydrofuran

CASRN 109-99-9 | DTXSID1021328

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System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Developmental	9 x 10 ^-1	Decreased pup body weight gain	BMDL _1SD : 928 mg/kg-day	1000	Low/Medium

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous, Hepatic	2	Increased liver weight and centrilobular cytomegaly, CNS effects (narcosis)	BMCL ₁₀ : 246.0 mg/m³	100	Medium/High

Weight of Evidence for Cancer (PDF) (26 pp, 242 K) Last Updated: 02/21/2012

WOE Characterization	Framework for WOE Characterization
Suggestive evidence of carcinogenic potential	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for THF provides "suggestive evidence of carcinogenic potential."
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.