Libby Amphibole Asbestos
CASRN 1318-09-8 | DTXSID70873869
- Toxicological Review (PDF) (685 pp, 8.45 M)
- IRIS Summary (PDF) (36 pp, 359 K)
- Supporting Documents for Libby Amphibole Asbestos
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(36 pp, 359 K)
Last Updated: 12/08/2014
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(36 pp, 359 K)
Last Updated: 12/08/2014
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Respiratory | 9 x 10 -5 | Localized pleural thickening |
BMCL
10
:
2.6
x 10-2 fiber/cc |
300 | Medium |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(36 pp, 359 K)
Last Updated: 12/08/2014
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Carcinogenic to humans (Inhalation route) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), Libby Amphibole asbestos (LAA) is "carcinogenic to humans" following inhalation exposure based on epidemiologic evidence that shows a convincing association between exposure to LAA fibers and increased lung cancer and mesothelioma mortality.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (36 pp, 359 K)
Not Assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (36 pp, 359 K)
Inhalation Unit Risk:
1.7
x 10-1
per fiber/cc
Extrapolation Method: Linear low dose extrapolation below the POD.
Tumor site(s): Respiratory
Tumor type(s): Cancer mortality from lung cancer and mesothelioma (Sullivan, 2007)
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- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
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