IRIS

Ethyl Tertiary Butyl Ether (ETBE)

CASRN 637-92-3 | DTXSID0025604

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (8 pp, 298 K) Last Updated: 08/13/2021

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Urinary 1 Increased absolute kidney weight in female rats BMDL 10 (HED): 2.88 x 101
mg/kg-day
30 High

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (8 pp, 298 K) Last Updated: 08/13/2021

System RfC (mg/m3) Basis PoD Composite UF Confidence
Urinary 4 x 10 1 Increased absolute kidney weight in female rats NOAEL : 1.11 x 103
mg/m3
30 Medium

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (8 pp, 298 K) Last Updated: 08/13/2021

WOE Characterization Framework for WOE Characterization
Suggestive evidence of carcinogenic potential (Inhalation route) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), ethyl tertiary butyl ether has “suggestive evidence of carcinogenic potential" for the inhalation route and “inadequate information to assess carcinogenic potential” for the oral route.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (8 pp, 298 K)

Information reviewed but value not estimated.


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (8 pp, 298 K)


Inhalation Unit Risk: 8 x 10-5 mg/m3
Extrapolation Method: Linear extrapolation from the POD ((BMCL10(HED)) associated with 10% extra cancer risk.
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas and carcinomas (Saito et al. 2013; JPEC, 2010b)


Additional EPA toxicity information may be available by visiting the following sites:

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