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tert-Butyl Alcohol (tBA)

CASRN 75-65-0 | DTXSID8020204

  • Toxicological Review (PDF) (156 pp, 2.44 M)
  • IRIS Executive Summary (PDF) (7 pp, 310 K)
  • Supplemental Information on the IRIS Toxicological Review of Tert-Butyl Alcohol

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (7 pp, 310 K) Last Updated: 08/13/2021

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Urinary 4 x 10 -1 Increased severity of nephropathy BMDL 10 (HED): 43.2
mg/kg-day
100 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (7 pp, 310 K) Last Updated: 08/13/2021

System RfC (mg/m3) Basis PoD Composite UF Confidence
Urinary 5 Increased severity of nephropathy BMCL 10 (HEC): 491
mg/m3
100 Medium

Cancer Assessment

Weight of Evidence for Cancer (PDF) (7 pp, 310 K) Last Updated: 08/13/2021

WOE Characterization Framework for WOE Characterization
Suggestive evidence of carcinogenic potential Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under EPA’s Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), tert-butyl alcohol has “suggestive evidence of carcinogenic potential” for all routes of exposure based on some evidence in animals.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (7 pp, 310 K)

Suggestive evidence of carcinogenic potential

Oral Slope Factor: 5 x 10-4 per mg/kg-day (OSF based on increasing thyroid tumors in mice. )
Tumor site(s): Urinary, Endocrine
Tumor type(s): Renal adenomas and carcinomas, thyroid adenomas ((NTP, 1995))


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (7 pp, 310 K)

No PBPK model of tert-butyl alcohol in mice is available; therefore route to route extrapolation (oral to inhalation) cannot be performed at this time.

Chemical Documents

Aug 2021: IRIS Toxicological Review of Tert-Butyl Alcohol (Tert-Butanol or TBA) (Final Report) (Report)

Jul 2020: IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Interagency Science Discussion Draft, 2020) (Report)

Jun 2017: IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (External Review Draft, 2017) (Report)

May 2016: IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Public Comment Draft, 2016) (Report)

Sep 2014: IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Interagency Science Consultation Draft, 2014) (Report)

Aug 2013: IRIS Toxicological Review of Tert-Butyl Alcohol (TBA) (Preliminary Assessment Materials, 2013) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - tert-Butyl Alcohol (tBA)
  • eChemPortal - tert-Butyl Alcohol (tBA)

Critical Effects

Urinary
Urinary

Tumor Sites

Endocrine
Endocrine

Urinary
Urinary

Chemical Structure

tert-Butyl Alcohol (tBA)

Synonyms

  • NCI-C55367
  • TBA
  • arconol
  • t-butanol
  • t-butyl alcohol
  • t-butyl hydroxide
  • tBA
  • tert-butanol
  • tert-butyl alcohol
  • tert-butylalcohol
  • tertiary carbinol
  • trimethyl carbinol
  • trimethyl methanol
  • trimethylcarbinol
  • trimethylmethanol
  • 1,1-dimethylethanol
  • 2 methylpropan-2-ol
  • 2 metilpropan-2-ol
  • 2-Propanol
  • 2-methyl-
  • 2-methyl-2-propanol
  • 2-methylpropan-2-ol
  • 2-methylpropane-2-ol
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