Tetrachloroethylene (Perchloroethylene)

Reference Dose for Oral Exposure (RfD) (PDF) (38 pp, 350 K) Last Updated: 02/10/2012

Note: The RfD was derived as a midpoint of two candidate RfDs from studies that reported neurotoxicity in occupationally-exposed adults: 0.0097 mg/kg-day based on changes in reaction time and cognitive effects (Echeverria et al., 1995) and 0.0026 mg/kg-day based on changes in color vision (Cavalleri et al., 1994). See Section I.A.1 of the IRIS Summary for Tetrachloroethylene for more information.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (38 pp, 350 K) Last Updated: 02/10/2012

Note: The RfC was derived as a midpoint of two candidate RfCs from studies that reported neurotoxicity in occupationally-exposed adults: 0.056 mg/m³ based on changes in reaction time and cognitive effects (Echeverria et al., 1995) and 0.015 mg/m³ based on changes in color vision (Cavalleri et al., 1994). See Section I.B.1 of the IRIS Summary for Tetrachloroethylene for more information.

Weight of Evidence for Cancer (PDF) (38 pp, 350 K) Last Updated: 02/10/2012

• Following EPA (2005a) Guidelines for Carcinogen Risk Assessment, tetrachloroethylene is "likely to be carcinogenic in humans by all routes of exposure."
• This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (38 pp, 350 K)

Inhalation Unit Risk: 2.6 x 10^-7 per µg/m³
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (BMCL10), followed by extrapolation to humans using the PBPK model of Chiu and Ginsberg (2011).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (JISA, 1993)