IRIS

1,2,4-Trichlorobenzene

CASRN 120-82-1 | DTXSID0021965

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 118 K) Last Updated: 05/01/1992

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Endocrine 1 x 10 -2 Increased adrenal weights; vacuolization of zona fasciculata in the cortex NOAEL : 1.48 x 101
mg/kg-day
1000 Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 118 K)
Not assessed under the IRIS Program.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (14 pp, 118 K) Last Updated: 06/01/1989

WOE Characterization Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • A dermal exposure study in mice was found inadequate for drawing conclusions as to carcinogenicity in humans.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 118 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 118 K)

Not assessed under the IRIS Program.


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