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2,4,6-Trichlorophenol

CASRN 88-06-2 | DTXSID5021386

  • IRIS Summary (PDF) (13 pp, 115 K)

On this page:

  • Key IRIS
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K) Last Updated:

Not assessed under the IRIS Program.


Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K) Last Updated: 07/01/1991

Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 115 K) Last Updated: 06/01/1990

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Based on no human data and sufficient evidence in animals; namely, increased incidence of lymphomas or leukemias in male rats and hepatocellular adenomas or carcinomas in male and female mice.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)

Oral Slope Factor: 1.1 x 10-2 per mg/kg-day
Drinking Water Unit Risk: 3.1 x 10-7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hematologic
Tumor type(s): Leukemia (NCI, 1979)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)

Inhalation Unit Risk: 3.1 x 10-6 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hematologic
Tumor type(s): Leukemia (NCI, 1979)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - 2,4,6-Trichlorophenol
  • eChemPortal - Trichlorophenol

Tumor Sites

Hematologic
Hematologic

Chemical Structure

2,4,6-Trichlorophenol

Synonyms

  • Dowicide 2s
  • NCI-C02904
  • Omal
  • Phenachlor
  • Phenol, 2,4,6-trichloro-
  • RCRA Waste Number U231
  • Trichlorophenol
  • Trichlorophenol, 2,4,6-
  • 2,4,6-Trichlorophenol
  • 88-06-2
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