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Benzidine

CASRN 92-87-5 | DTXSID2020137

  • IRIS Summary (PDF) (16 pp, 129 K)

On this page:

  • Key IRIS
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (16 pp, 129 K) Last Updated: 01/01/1989

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous, Hepatic 3 x 10 -3 Brain cell vacuolization; liver cell alterations in females LOAEL : 2.7
mg/kg-day
1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (16 pp, 129 K) Last Updated: 07/01/1991

Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (16 pp, 129 K) Last Updated: 03/31/1987

WOE Characterization Framework for WOE Characterization
A (Human carcinogen) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Observation of increased incidence of bladder cancer and bladder cancer-related deaths in exposed workers
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (16 pp, 129 K)

Oral Slope Factor: 2.3 x 102 per mg/kg-day
Drinking Water Unit Risk: 6.7 x 10-3 per µg/L
Extrapolation Method: One-hit with time factor, extra risk
Tumor site(s): Urinary
Tumor type(s): Bladder tumors (Zavon, 1973)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (16 pp, 129 K)

Inhalation Unit Risk: 6.7 x 10-2 per µg/m3
Extrapolation Method: One-hit with time factor, extra risk
Tumor site(s): Urinary
Tumor type(s): Bladder tumors (Zavon, 1973)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Benzidine
  • eChemPortal - Benzidine

Critical Effects

Hepatic
Hepatic

Nervous
Nervous

Tumor Sites

Urinary
Urinary

Chemical Structure

Benzidine

Synonyms

  • Benzidin
  • Benzidina
  • Benzidine
  • Benzydyna
  • Biphenyl, 4,4'-diamino-
  • C.I. Azoic Diazo Component 112
  • C.I.. 37225
  • Fast Corinth Base B
  • NCI-C03361
  • RCRA Waste Number u021
  • UN 1885
  • p,p'-Bianiline
  • p,p'-Diaminobiphenyl
  • p,p'-Dianiline
  • p-Diaminodiphenyl
  • (1,1'-Biphenyl)-4,4'-diamine
  • 4,4'-Bianiline
  • 4,4'-Biphenyldiamine
  • 4,4'-Biphenylenediamine
  • 4,4'-Diamino-1,1'-biphenyl
  • 4,4'-Diaminobiphenyl
  • 4,4'-Diaminodiphenyl
  • 4,4'-Diphenylenediamine
  • 92-87-5
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