Benzidine
CASRN 92-87-5 | DTXSID2020137
- IRIS Summary (PDF) (16 pp, 129 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (16 pp, 129 K) Last Updated: 01/01/1989
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous, Hepatic | 3 x 10 -3 | Brain cell vacuolization; liver cell alterations in females |
LOAEL
:
2.7
mg/kg-day |
1000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (16 pp, 129 K) Last Updated: 07/01/1991
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(16 pp, 129 K)
Last Updated: 03/31/1987
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| A (Human carcinogen) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Observation of increased incidence of bladder cancer and bladder cancer-related deaths in exposed workers
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (16 pp, 129 K)
Oral Slope Factor:
2.3
x 102
per mg/kg-day
Drinking Water Unit Risk:
6.7
x 10-3
per µg/L
Extrapolation Method: One-hit with time factor, extra risk
Tumor site(s): Urinary
Tumor type(s): Bladder tumors (Zavon, 1973)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (16 pp, 129 K)
Inhalation Unit Risk:
6.7
x 10-2
per µg/m3
Extrapolation Method: One-hit with time factor, extra risk
Tumor site(s): Urinary
Tumor type(s): Bladder tumors (Zavon, 1973)
Other EPA Information
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Related Links
Tumor Sites
Chemical Structure
Synonyms
- Benzidin
- Benzidina
- Benzidine
- Benzydyna
- Biphenyl, 4,4'-diamino-
- C.I. Azoic Diazo Component 112
- C.I.. 37225
- Fast Corinth Base B
- NCI-C03361
- RCRA Waste Number u021
- UN 1885
- p,p'-Bianiline
- p,p'-Diaminobiphenyl
- p,p'-Dianiline
- p-Diaminodiphenyl
- (1,1'-Biphenyl)-4,4'-diamine
- 4,4'-Bianiline
- 4,4'-Biphenyldiamine
- 4,4'-Biphenylenediamine
- 4,4'-Diamino-1,1'-biphenyl
- 4,4'-Diaminobiphenyl
- 4,4'-Diaminodiphenyl
- 4,4'-Diphenylenediamine
- 92-87-5