Di (2-ethylhexyl)phthalate (DEHP)
CASRN 117-81-7 | DTXSID5020607
- IRIS Summary (PDF) (14 pp, 121 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(14 pp, 121 K)
Last Updated: 01/31/1987
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 2 x 10 -2 | Increased relative liver weight |
LOAEL
:
1.9
x 101 mg/kg-day |
1000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(14 pp, 121 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(14 pp, 121 K)
Last Updated: 09/07/1988
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Orally administered DEHP produced significant dose-related increases in liver tumor responses in rats and mice of both sexes.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 121 K)
Oral Slope Factor:
1.4
x 10-2
per mg/kg-day
Drinking Water Unit Risk:
4
x 10-7
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma and adenoma (NTP, 1982)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 121 K)
Not Assessed under the IRIS Program.
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