p,p'-Dichlorodiphenyltrichloroethane (DDT)

CASRN 50-29-3 | DTXSID4020375

IRIS Summary (PDF) (17 pp, 133 K)
Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

On this page:

IRIS Toxicity
Values
Other EPA
Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (17 pp, 133 K) Last Updated: 03/31/1987

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Hepatic	5 x 10 ^-4	Liver lesions	NOEL : 5 x 10^-2 mg/kg-day	100	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (17 pp, 133 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (17 pp, 133 K) Last Updated: 08/22/1988

WOE Characterization	Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Observation of tumors (generally of the liver) in seven studies in various mouse strains and three studies in rats. DDT is structurally similar to other probable carcinogens, such as DDD and DDE.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (17 pp, 133 K)

Oral Slope Factor: 3.4 x 10^-1 per mg/kg-day
Drinking Water Unit Risk: 9.7 x 10^-6 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver tumors, benign and malignant (Turusov et al., 1973; Terracini et al., 1973; Thorpe and Walker, 1973; Tomatis and Turusov, 1975; Cabral et al., 1982; Rossi et al., 1977)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (17 pp, 133 K)

Inhalation Unit Risk: 9.7 x 10^-5 per µg/m³
Extrapolation Method: Linear multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver tumors, benign and malignant (Turusov et al., 1973; Terracini et al., 1973; Thorpe and Walker, 1973; Tomatis and Turusov, 1975; Cabral et al., 1982; Rossi et al., 1977)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

p,p'-Dichlorodiphenyltrichloroethane (DDT)

CASRN 50-29-3 | DTXSID4020375

Noncancer Assessment

Cancer Assessment

Other EPA Information

Related Links

Critical Effects

Tumor Sites

Chemical Structure

Synonyms