Bromomethane CASRN 74-83-9 | IRIS

IRIS

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Gastrointestinal	1.4 x 10 ^-3	Epithelial hyperplasia of the forestomach	NOAEL : 1.4 mg/kg-day	1000	Medium

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous, Respiratory	5 x 10 ^-3	Degenerative and proliferative lesions of the olfactory epithelium of the nasal cavity	LOAEL (HEC): 4.8 x 10^-1 mg/m³	100	High

Weight of Evidence for Cancer (PDF) (29 pp, 184 K) Last Updated: 06/01/1989

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Inadequate human and animal data: a single mortality study from which direct exposure associations could not be deduced and studies in several animal species with too few animals, too brief exposure or observation time for adequate power. Bromomethane has shown genotoxicity.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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