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Dichlorvos

CASRN 62-73-7 | DTXSID5020449

  • IRIS Summary (PDF) (33 pp, 201 K)
  • Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

On this page:

  • IRIS Toxicity
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (33 pp, 201 K) Last Updated: 11/01/1993

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous 5 x 10 -4 Plasma and RBC ChE inhibition in males and females brain ChE inhibition in males NOAEL : 5 x 10-2
mg/kg-day
100 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (33 pp, 201 K) Last Updated: 06/01/1994

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous 5 x 10 -4 Decreased brain cholinesterase activity NOAEL (HEC): 5 x 10-2
mg/m3
100 Medium

Cancer Assessment

Weight of Evidence for Cancer (PDF) (33 pp, 201 K) Last Updated: 10/01/1989

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Significant increases in forestomach tumors in female and male B6C3F1 mice and leukemias and pancreatic acinar adenomas in Fischer 344 rats. Supporting evidence included observation of tumors at other sites in the rat and observation of mutagenicity for both dichlorvos and a major metabolite dichloroacetaldehyde. A structurally related material, dichloropropene, also induces forestomach tumors in rodents.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (33 pp, 201 K)

Oral Slope Factor: 2.9 x 10-1 per mg/kg-day
Drinking Water Unit Risk: 8.3 x 10-6 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hematologic, Endocrine, Gastrointestinal
Tumor type(s): Forestomach tumors, pancreatic acinar adenoma, leukemia (NTP, 1986a,b)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (33 pp, 201 K)

Not Assessed under the IRIS Program.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Dichlorvos
  • eChemPortal - Dichlorvos

Critical Effects

Nervous
Nervous

Tumor Sites

Endocrine
Endocrine

Gastrointestinal
Gastrointestinal

Hematologic
Hematologic

Chemical Structure

Dichlorvos

Synonyms

  • Aapona insecticide
  • Astrobot
  • Atgard
  • Atgard V
  • Bay-19149
  • Bibesol
  • Brevinyl
  • Brevinyl E50
  • Brevinyl Weedat 0002
  • Canogard
  • Cekusan
  • Celcusan
  • Chlorvinphos
  • Cyanophos
  • DDVF
  • DDVP
  • Dedevap
  • Deriban
  • Derribante
  • Dichlorman
  • Dichlorophos
  • Dichlorovas
  • Dichlorovos
  • Dichlorphos
  • Dichlorvos
  • Dimethyl 2,2-dichloroethenyl phosphate
  • Dimethyl 2,2-dichlorovinyl phosphate
  • Dimethyl dichlorovinyl phosphate
  • Divipan
  • ENT 20738
  • Equigard
  • Equigel
  • Estrosel
  • Estrosol
  • Ethenol, 2,2-dichloro-, dimethyl phosphate
  • Fecama
  • Fly Fighter
  • Fly-Die
  • Herkal
  • Herkol
  • Krecalvin
  • Mafu
  • Marvex
  • Mopari UN NA 2783
  • NCI-C00113
  • NSC-6738
  • Nerkol
  • No-Pest Strip
  • Nogos
  • Nogos 50
  • Nogos G
  • Nuva
  • Nuvan
  • Nuvan 100 EC
  • OKO
  • OMS 14
  • Phosphoric acid, 2,2-dichloroethenyl dimethyl ester
  • Phosphoric acid, 2,2-dichlorovinyl dimethyl ester
  • Phosvit
  • SD1750
  • Szklarniak
  • TAP 9VP
  • Task
  • Task Tabs
  • Tenac
  • UDVF
  • Unifos
  • Unifos 50 EC
  • Vapona
  • Vapona II
  • Vaponite
  • Verdican
  • Verdipor
  • Vinyl alcohol, 2,2-dichloro-, dimethyl phosphate
  • Vinylophos
  • o,o-Dimethyl dichlorovinyl phosphate
  • o,o-Dimethyl o-2,2-dichlorovinyl phosphate
  • 2,2-Dichloroethenyl phosphate
  • 2,2-Dichloroethenyl phosphoric acid dimethyl ester
  • 2,2-Dichlorovinyl dimethyl phosphate
  • 62-73-7
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