IRIS

Hexachloroethane

CASRN 67-72-1 | DTXSID7020689

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (34 pp, 308 K) Last Updated: 09/23/2011

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (34 pp, 308 K) Last Updated: 09/23/2011

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (34 pp, 308 K) Last Updated: 09/23/2011

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under the U.S. EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), HCE is "likely to be carcinogenic to humans" based on evidence of multiple tumor types in both sexes of rats and mice (NTP, 1989 NCI, 1978).
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (34 pp, 308 K)

Oral Slope Factor: 4 x 10-2 per mg/kg-day
Drinking Water Unit Risk: 1 x 10-6 per µg/L
Extrapolation Method: The multistage model with linear extrapolation from the point of departure (LED10).
Tumor site(s): Urinary
Tumor type(s): Renal adenomas and carcinomas (combined) (NTP (1989))


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (34 pp, 308 K)

Information reviewed but value not estimated.

You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.

Contact Us to ask a question, provide feedback or report a problem.