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Hexachloroethane

CASRN 67-72-1 | DTXSID7020689

  • Toxicological Review (PDF) (200 pp, 1.61 M)
  • IRIS Summary (PDF) (34 pp, 308 K)

On this page:

  • Key IRIS
    Values
  • Chemical
    Documents
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (34 pp, 308 K) Last Updated: 09/23/2011

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Urinary 7 x 10 -4 Atrophy and degeneration of renal tubules BMDL 10 : 0.728
mg/kg-day
1000 Low/Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (34 pp, 308 K) Last Updated: 09/23/2011

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous 3 x 10 -2 Neurotoxicity (tremors and ruffled pelt) NOAEL (HEC): 83
mg/m3
3000 Low

Cancer Assessment

Weight of Evidence for Cancer (PDF) (34 pp, 308 K) Last Updated: 09/23/2011

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under the U.S. EPA Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005b), HCE is "likely to be carcinogenic to humans" based on evidence of multiple tumor types in both sexes of rats and mice (NTP, 1989 NCI, 1978).
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (34 pp, 308 K)

Oral Slope Factor: 4 x 10-2 per mg/kg-day
Drinking Water Unit Risk: 1 x 10-6 per µg/L
Extrapolation Method: The multistage model with linear extrapolation from the point of departure (LED10).
Tumor site(s): Urinary
Tumor type(s): Renal adenomas and carcinomas (combined) (NTP (1989))


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (34 pp, 308 K)

Information reviewed but value not estimated.

Chemical Documents

Jul 2011: IRIS Toxicological Review of Hexachloroethane (Final Report) (Report)

May 2011: IRIS Toxicological Review of Hexachloroethane (Interagency Science Discussion Draft) (Report)

May 2010: IRIS Toxicological Review of Hexachloroethane (External Review Draft) (Report)

Apr 2010: IRIS Toxicological Review of Hexachloroethane (Interagency Science Consultation Draft) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Hexachloroethane
  • eChemPortal - Hexachloroethane

Critical Effects

Nervous
Nervous

Urinary
Urinary

Tumor Sites

Urinary
Urinary

Chemical Structure

Hexachloroethane

Synonyms

  • Avlothane
  • Carbon hexachloride
  • Distokal
  • Distopan
  • Distopin
  • Egitol
  • Ethane hexachloride
  • Ethylene hexachloride
  • Falkitol
  • Fasciolin
  • Hexachlor-aethan
  • Hexachloroethane
  • Hexachloroethylene
  • Mottenhexe
  • NA 9037
  • NCI-C04604
  • Perchloroethane
  • Phenohep
  • RCRA Waste Number U131
  • 1,1,1,2,2,2-Hexachloroethane
  • 67-72-1
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