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N-Nitrosodi-N-propylamine

CASRN 621-64-7 | DTXSID6021032

  • IRIS Summary (PDF) (11 pp, 104 K)

On this page:

  • Key IRIS
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (11 pp, 104 K) Last Updated:

Not assessed under the IRIS Program.


Reference Concentration for Inhalation Exposure (RfC) (PDF) (11 pp, 104 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (11 pp, 104 K) Last Updated: 03/31/1987

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Increased tumor incidence at multiple sites in two rodent species and in monkeys administered the compound by various routes
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (11 pp, 104 K)

Oral Slope Factor: 7.0 per mg/kg-day
Drinking Water Unit Risk: 2.0 x 10-4 per µg/L
Extrapolation Method: One-hit
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinomas (Druckrey, 1967; Druckrey et al., 1967)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (11 pp, 104 K)

Not Assessed under the IRIS Program.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - N-Nitrosodi-N-propylamine
  • eChemPortal - Nitrosodi-N-propylamine

Tumor Sites

Hepatic
Hepatic

Chemical Structure

N-Nitrosodi-N-propylamine

Synonyms

  • Dipropylamine, n-nitroso-
  • Dipropylnitrosamine
  • Dpn
  • Dpna
  • Ndpa
  • Nitrosodi-N-propylamine
  • Propanamine, n-nitroso-n-propyl-
  • Propylamine, n-nitroso-n-di-
  • RCRA Waste Number U111
  • di-n-Propylnitrosamine
  • n-Nitroso-n-propyl-1-propanamine
  • n-Nitrosodi-n-propylamine
  • n-Nitrosodi-n-propylamine
  • n-Nitrosodipropylamine
  • 621-64-7
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