N-Nitroso-N-methylethylamine

CASRN 10595-95-6 | DTXSID6021036

IRIS Summary (PDF) (9 pp, 96 K)

On this page:

Key IRIS
Values
Other EPA
Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (9 pp, 96 K) Last Updated:

Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (9 pp, 96 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (9 pp, 96 K) Last Updated: 03/01/1988

WOE Characterization	Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Increased incidence of tumors of the liver and other sites in two rat strains
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (9 pp, 96 K)

Oral Slope Factor: 2.2 x 10¹ per mg/kg-day
Drinking Water Unit Risk: 6.3 x 10^-4 per µg/L
Extrapolation Method: One-hit
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinomas (Druckrey, 1967; Druckrey et al., 1967)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (9 pp, 96 K)

Not Assessed under the IRIS Program.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

N-Nitroso-N-methylethylamine

CASRN 10595-95-6 | DTXSID6021036

Noncancer Assessment

Cancer Assessment

Other EPA Information

Related Links

Tumor Sites

Chemical Structure

Synonyms