IRIS

1,1,2,2-Tetrachloroethane

CASRN 79-34-5 | DTXSID7021318

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (29 pp, 250 K) Last Updated: 09/30/2010

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic 5 x 10 -2
(Subchronic)
Increased relative liver weight in rats BMDL 1SD : 15
mg/kg-day
300 Medium
Hepatic 2 x 10 -2
(Chronic)
Increased relative liver weight in rats BMDL 1SD : 15
mg/kg-day
1000 Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (29 pp, 250 K) Last Updated: 09/30/2010
Information reviewed but value not estimated.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (29 pp, 250 K) Last Updated: 09/30/2010

WOE Characterization Framework for WOE Characterization
Likely to be carcinogenic to humans Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)
Basis:
  • Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a) 1,1,2,2-tetrachloroethane is "likely to be carcinogenic to humans."
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (29 pp, 250 K)

Oral Slope Factor: 2 x 10-1 per mg/kg-day
Drinking Water Unit Risk: 6 x 10-6 per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (LED10).
Tumor site(s): Hepatic
Tumor type(s): hepatocellular carcinomas (NCI, 1978)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (29 pp, 250 K)

Information reviewed but value not estimated.

Additional EPA toxicity information may be available by visiting the following sites:

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