1,1,1-Trichloroethane
CASRN 71-55-6 | DTXSID0021381
- Toxicological Review (PDF) (237 pp, 1.08 M)
- IRIS Summary (PDF) (55 pp, 386 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (55 pp, 386 K) Last Updated: 09/28/2007
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Other |
2
(Chronic) |
Reduced body weight |
BMDL
10
:
2155
mg/kg-day |
1000 | Low/Medium |
| Other |
7
(Subchronic) |
Reduced body weight |
BMDL
10
:
2155
mg/kg-day |
300 | Low/Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (55 pp, 386 K) Last Updated: 09/28/2007
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous |
5
(Short-term) |
Performance on neurobehavioral tests |
LOAEL
:
526
mg/m3 |
100 | Medium |
| Nervous |
6
(Acute: 24 hours) |
Performance on neurobehavioral tests |
LOAEL
:
950
mg/m3 |
100 | Medium |
| Hepatic |
5
(Chronic) |
Liver histopathologic changes |
NOAEL
(HEC):
1553
mg/m3 |
100 | Medium |
| Hepatic |
5
(Subchronic) |
Liver histopathologic changes |
NOAEL
(HEC):
1553
mg/m3 |
100 | Medium |
| Nervous |
7
(Acute: 8 hours) |
Performance on neurobehavioral tests |
LOAEL
:
950
mg/m3 |
100 | Medium |
| Nervous |
7
(Acute: 4 hours) |
Performance on neurobehavioral tests |
LOAEL
:
950
mg/m3 |
100 | Medium |
| Nervous |
9
(Acute: 1 hour) |
Performance on neurobehavioral tests |
LOAEL
:
950
mg/m3 |
100 | Medium |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(55 pp, 386 K)
Last Updated: 09/28/2007
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Inadequate information to assess carcinogenic potential | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for 1,1,1-trichloroethane provides "inadequate information to assess carcinogenic potential."
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (55 pp, 386 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (55 pp, 386 K)
Not assessed under the IRIS Program.
Chemical Documents
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Chemical Structure
Synonyms
- Aerothene MM
- Aerothene tt
- Algylen
- Alpha-t
- Baltana
- CF 2
- Chloroetene
- Chloroethane-NU
- Chloroethene
- Chloroethene nu
- Chloroform, methyl-
- Chlorothane nu
- Chlorothene
- Chlorothene SM
- Chlorothene nu
- Chlorothene vg
- Chlorten
- Chlorylen
- Dowclene LS
- Ethane, 1,1,1-trichloro-
- Gemalgene
- Genklene LB
- ICI-CF 2
- Inhibisol
- Methylchloroform
- Methyltrichloromethane
- NCI-C04626
- RCRA Waste Number U226
- Solvent 111
- TCEA
- Trichloran
- Trichloroethane, 1,1,1-
- Trichloromethylmethane
- Trielene
- UN 2831
- alpha-Trichloroethane
- tri-Ethane
- 1,1,1-TCA
- 1,1,1-TCE
- 71-55-6