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1,1,2-Trichloroethane

CASRN 79-00-5 | DTXSID5021380

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Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K) Last Updated: 09/26/1988

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Immune, Hematologic 4 x 10 -3 Clinical serum chemistry (effects on erythrocytes and depressed humoral immune status) NOAEL : 3.9
mg/kg-day 		1000 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 115 K) Last Updated: 03/31/1987

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Hepatocellular carcinomas and pheochromocytomas in one strain of mice forms the basis for this classification. Carcinogenicity was not shown in rats. 1,1,2-Trichloroethane is structurally related to 1,2-dichloroethane, a probable human carcinogen.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)

Oral Slope Factor: 5.7 x 10-2 per mg/kg-day
Drinking Water Unit Risk: 1.6 x 10-6 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma (NCI, 1978)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)

Inhalation Unit Risk: 1.6 x 10-5 per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma (NCI, 1978)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:

Related Links

Critical Effects

Hematologic
Hematologic

Immune
Immune

Tumor Sites

Hepatic
Hepatic

Chemical Structure

1,1,2-Trichloroethane

Synonyms

  • Beta-t
  • Ethane trichloride
  • Ethane, 1,1,2-trichloro-
  • NCI-C04579
  • RCRA Waste Number U227
  • RCRA Waste Number U359
  • Trichloroethane
  • Trichloroethane, 1,1,2-
  • Trojchloroetan(1,1,2)
  • Vinyl Trichloride
  • beta-Trichloroethane
  • 1,1,2-Trichlorethane
  • 1,1,2-Trichloroethane
  • 1,2,2-Trichloroethane
  • 79-00-5
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