Acetonitrile CASRN 75-05-8 | IRIS

IRIS

Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 165 K) Last Updated: 03/03/1999
Information reviewed but value not estimated.

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Other	6 x 10 ^-2	Mortality	NOAEL (HEC): 6.0 x 10¹ mg/m³	100 MF: 10	Medium

Weight of Evidence for Cancer (PDF) (23 pp, 165 K) Last Updated: 03/03/1999

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Carcinogenic potential cannot be determined	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

Under the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), the carcinogenic potential of ACN following inhalation, oral, or dermal exposure is best characterized as "cannot be determined because the existing evidence is composed of conflicting data (e.g., some evidence is suggestive of carcinogenic effects, but other equally pertinent evidence does not confirm any concern)."
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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