Bromodichloromethane
CASRN 75-27-4 | DTXSID1020198
- IRIS Summary (PDF) (18 pp, 135 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (18 pp, 135 K) Last Updated: 09/30/1987
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Urinary | 2 x 10 -2 | Renal cytomegaly |
LOAEL
:
1.79
x 101
mg/kg-day |
1000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (18 pp, 135 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(18 pp, 135 K)
Last Updated: 02/01/1993
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Based on inadequate human data and sufficient evidence of carcinogenicity in two animal species (mice and rats) as shown by increased incidence of kidney tumors and tumors of the large intestine in male and female rats, kidney tumors in male mice, and liver tumors in female mice.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (18 pp, 135 K)
Oral Slope Factor:
6.2
x 10-2
per mg/kg-day
Drinking Water Unit Risk:
1.8
x 10-6
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Urinary
Tumor type(s): Kidney (tubular cell adenoma and tubular cell adenocarcinoma) (NTP, 1987)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (18 pp, 135 K)
Not Assessed under the IRIS Program.
Other EPA Information
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Critical Effects
Tumor Sites
Chemical Structure
Synonyms
- Bromodichloromethane
- Dichlorobromomethane
- Dichloromonobromomethane
- Methane, bromodichloro-
- Monobromodichloromethane
- 75-27-4