Dieldrin

CASRN 60-57-1 | DTXSID9020453

IRIS Summary (PDF) (18 pp, 135 K)

On this page:

Key IRIS
Values
Other EPA
Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (18 pp, 135 K) Last Updated: 09/07/1988

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Hepatic	5 x 10 ^-5	Liver lesions	NOAEL : 5 x 10^-3 mg/kg-day	100	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (18 pp, 135 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (18 pp, 135 K) Last Updated: 09/07/1988

WOE Characterization	Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Dieldrin is carcinogenic in seven strains of mice when administered orally. Dieldrin is structurally related to compounds (aldrin, chlordane, heptachlor, heptachlor epoxide, and chlorendic acid) which produce tumors in rodents.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (18 pp, 135 K)

Oral Slope Factor: 1.6 x 10¹ per mg/kg-day
Drinking Water Unit Risk: 4.6 x 10^-4 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver carcinoma (Davis (1965), reevaluated by Reuber, 1974 (cited in Epstein, 1975a); Walker et al., 1972; Thorpe and Walker, 1973; NCI, 1978a,b; Tennekes et al., 1981; Meierhenry et al., 1983)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (18 pp, 135 K)

Inhalation Unit Risk: 4.6 x 10^-3 per µg/m³
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Liver carcinoma (Davis (1965), reevaluated by Reuber, 1974 (cited in Epstein, 1975a); Walker et al., 1972; Thorpe and Walker, 1973; NCI, 1978a,b; Tennekes et al., 1981; Meierhenry et al., 1983)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Dieldrin

CASRN 60-57-1 | DTXSID9020453

Noncancer Assessment

Cancer Assessment

Other EPA Information

Related Links

Critical Effects

Tumor Sites

Chemical Structure

Synonyms