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Folpet

CASRN 133-07-3 | DTXSID0021385

  • Archived IRIS Summary (PDF) (13 pp, 115 K)
  • Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

Alert
Alert Notice - This webpage has been Archived

Archive Disclaimer - This site contains archived material.
This web page has been archived and is maintained for reference purposes only. Persons with disabilities having difficulty accessing archived materials may contact the IRIS Hotline for assistance. Please use the contact us form if you need immediate assistance.

On this page:

  • IRIS Toxicity
    Values
  • Other EPA
    Information

This information is archived and for historical reference only.

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (13 pp, 115 K) Archived on: 07/15/2016

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Hepatic, Other 1 x 10 -1 Decreased body weight gain, altered serum chemistry parameters (decreased serum cholesterol, total protein, and serum albumin and globulin levels) NOEL : 1.0 x 101
mg/kg-day
100 High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (13 pp, 115 K) Archived on: 07/15/2016

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (13 pp, 115 K) Archived on: 07/15/2016

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Folpet has induced carcinoma and adenoma of the duodenum (an unusual site) in both sexes of both CD-1 and B6C3F1 mice. Folpet is also mutagenic in several in vitro assays and is a structural analogue of captan, which has been shown to induce carcinoma in the duodenum of two mouse strains.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 115 K)

Oral Slope Factor: 3.5 x 10-3 per mg/kg-day
Drinking Water Unit Risk: 1.0 x 10-7 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Gastrointestinal
Tumor type(s): Digestive tract tumors (adenoma and/ or adenocarcinoma) (Chevron, 1982)


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 115 K)

Not Assessed under the IRIS Program.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Folpet
  • eChemPortal - Folpet

Critical Effects

Hepatic
Hepatic

Tumor Sites

Gastrointestinal
Gastrointestinal

Chemical Structure

Folpet

Synonyms

  • Folpan
  • Folpet
  • Ftalan
  • Orthophaltan
  • Phaltan
  • Phthaltan
  • Thiophal
  • Troysan anti-mildew o
  • n-(Trichlor-methylthio)-phthalamid
  • n-(Trichlormethylthio)phthalimide
  • n-(Trichloromethylmercpato)phthalimide
  • n-(Trichloromethylthio)phthalimide
  • 133-07-3
  • 1h-Isoindole-1,3(2h)-dione, 2-((trichloromethyl)thio)-
  • 2-((Trichloromethyl)thio)-1h-isoindole-1,3(2h)-dione
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