Skip to main content
U.S. flag

An official website of the United States government

Here’s how you know

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

HTTPS

Secure .gov websites use HTTPS
A lock ( Lock A locked padlock ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

  • Environmental Topics
  • Laws & Regulations
  • Report a Violation
  • About EPA
IRIS
Contact Us

Malathion

CASRN 121-75-5 | DTXSID4020791

  • IRIS Summary (PDF) (8 pp, 93 K)
  • Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

On this page:

  • IRIS Toxicity
    Values
  • Other EPA
    Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (8 pp, 93 K) Last Updated: 09/30/1987

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous 2 x 10 -2 RBC ChE depression NOEL : 2.3 x 10-1
mg/kg-day
10 Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (8 pp, 93 K)

Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (8 pp, 93 K)
Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (8 pp, 93 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (8 pp, 93 K)

Not assessed under the IRIS Program.

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:
  • Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
  • Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
  • Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

Related Links

  • EPA Chemicals Dashboard - Malathion
  • eChemPortal - Malathion

Critical Effects

Nervous
Nervous

Chemical Structure

Malathion

Synonyms

  • American cyanamid 4,409
  • Cabofos
  • Calmathion
  • Carbethoxy malathion
  • Carbetox
  • Carbophos
  • Chemathion
  • Cythion
  • Detmol ma 96%
  • Dicarboethoxyethyl o,o-dimethyl phosphorodithioate
  • Diethyl mercaptosuccinate, o,o-dimethyl dithiophosphate, s-ester
  • Diethyl mercaptosuccinate, o,o-dimethyl phosphorodithioate
  • Diethyl mercaptosuccinate, o,o-dimethyl thiophosphate
  • Dithiophosphate de o,o-dimethyle et de s-(1,2-dicarboethoxyethyle)
  • ENT 17,034
  • Emmatos extra
  • Ethiolacar
  • Formal
  • Fosfothion
  • Fosfotion
  • Fyfanon
  • Karbofos
  • Kop-thion
  • Kypfos
  • Malacide
  • Malagran
  • Malakill
  • Malamar
  • Malamar 50
  • Malaphele
  • Malaphos
  • Malaspray
  • Malathion
  • Malathon
  • Malation
  • Malatol
  • Malatox
  • Maldison
  • Malmed
  • Malphos
  • Maltox
  • Mercaptothion
  • Mercaptotion
  • Mlt
  • NCL-C00215
  • Oleophosphothion
  • Phosphothion
  • SF 60
  • Sadofos
  • Sadophos
  • Siptox 1
  • Sumitox
  • Vegfru
  • Zithiol
  • o,o-Dimethyl s-(1,2-bis(ethoxycarbonyl)ethyl)dithiophosphate
  • o,o-Dimethyl s-(1,2-dicarbethoxyethyl)phosphorodithioate
  • o,o-Dimethyl s-(1,2-dicarbethoxyethyl)thiothionphosphate
  • o,o-Dimethyl s-1,2-di(ethoxycarbamyl)ethyl phosphorodithioate
  • o,o-Dimethyl-s-(1,2-dicarbethoxyethyl) dithiophosphate
  • o,o-Dimethyl-s-1,2-dikarbetoxylethylditiofosfat
  • o,o-Dimethyldithiophosphate diethylmercaptosuccinate
  • s(1,2-bis(etossi-carbonil)-etil)-o,o-dimetil-ditiofosfato
  • s-(1,2-bis(Aethoxy-carbonyl)-aethyl)-o,o-dimethyldithiophasphat
  • s-(1,2-bis(Ethoxy-carbonyl)-ethyl)-o,o-dimethyldithiofosfaat
  • s-(1,2-bis(Ethoxycarbonyl)ethyl o,o-dimethyl phosphorodithioate
  • s-(1,2-di(Ethoxycarbonyl)ethyl dimethyl phosphorothiolothionate
  • s-1,2-bis(Ethoxycarbonyl)ethyl-o,o-dimethyl thiophosphate
  • 1,2-di(Ethoxycarbonyl)ethyl o,o-dimethyl phosphorodithioate
  • 121-75-5
  • IRIS Home
  • About IRIS
  • IRIS Recent Additions
  • IRIS Calendar
  • IRIS Assessments
  • Advanced Search
  • IRIS Program Materials
Contact Us to ask a question, provide feedback, or report a problem.
United States Environmental Protection Agency

Discover.

  • Accessibility Statement
  • Budget & Performance
  • Contracting
  • EPA www Web Snapshots
  • Grants
  • No FEAR Act Data
  • Privacy
  • Privacy and Security Notice

Connect.

  • Data.gov
  • Inspector General
  • Jobs
  • Newsroom
  • Open Government
  • Regulations.gov
  • Subscribe
  • USA.gov
  • White House

Ask.

  • Contact EPA
  • EPA Disclaimers
  • Hotlines
  • FOIA Requests
  • Frequent Questions

Follow.