Xylenes
CASRN 1330-20-7 | DTXSID2021446
- Toxicological Review (PDF) (113 pp, 498 K)
- IRIS Summary (PDF) (33 pp, 203 K)
On this page:
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF) (33 pp, 203 K) Last Updated: 02/21/2003
System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
---|---|---|---|---|---|
Other | 2 x 10 -1 | Decreased body weight, increased mortality |
NOAEL
:
1.79
x 102
mg/kg-day |
1000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF) (33 pp, 203 K) Last Updated: 02/21/2003
System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
---|---|---|---|---|---|
Nervous | 1 x 10 -1 | Impaired motor coordination (decreased rotarod performance) |
NOAEL
(HEC):
39
mg/m3 |
300 | Medium |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(33 pp, 203 K)
Last Updated: 02/21/2003
WOE Characterization | Framework for WOE Characterization |
---|---|
Data are inadequate for an assessment of human carcinogenic potential | Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999) |
- Under the Draft Revised Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999), data are inadequate for an assessment of the carcinogenic potential of xylenes. Adequate human data on the carcinogenicity of xylenes are not available, and the available animal data are inconclusive as to the ability of xylenes to cause a carcinogenic response. Evaluations of the genotoxic effects of xylenes have consistently given negative results.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (33 pp, 203 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (33 pp, 203 K)
Not assessed under the IRIS Program.
Chemical Documents
Other EPA Information
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
Related Links
Critical Effects
Chemical Structure
Synonyms
- Dimethylbenzene
- Mixed xylenes
- Xylenes
- m-Xylene
- meta-Xylene
- o-Xylene
- ortho-Xylene
- p-Xylene
- para-Xylene
- 1,2-Dimethylbenzene
- 1,3-Dimethylbenzene
- 1,4-Dimethylbenzene
- 106-42-3
- 108-38-3
- 1330-20-7
- 95-47-6