Nickel subsulfide

Reference Dose for Oral Exposure (RfD) (PDF) (11 pp, 109 K) Last Updated:

Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (11 pp, 109 K)

Not assessed under the IRIS Program.

Weight of Evidence for Cancer (PDF) (11 pp, 109 K) Last Updated: 09/30/1987

• Increased risks of lung and nasal cancer in humans exposed to nickel refinery dust, most of which was believed to have been nickel subsulfide; increased tumor incidences in animals by several routes of administration in several animal species and strains; and positive results in genotoxicity assays form the basis for this classification.
• This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (11 pp, 109 K)

Not Assessed under the IRIS Program.

Inhalation Unit Risk: 4.8 x 10^-4 per µg/m³
Extrapolation Method: Additive and multiplicative
Tumor site(s): Respiratory
Tumor type(s): Lung cancer (Enterline and Marsh, 1982; Chovil et al., 1981; Peto et al., 1984; Magnus et al., 1982)