IRIS

Acetaldehyde

CASRN 75-07-0 | DTXSID5039224

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (20 pp, 147 K) Last Updated:
Not assessed under the IRIS Program.

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (20 pp, 147 K) Last Updated: 10/01/1991

System RfC (mg/m3) Basis PoD Composite UF Confidence
Nervous, Respiratory 9 x 10 -3 Degeneration of olfactory epithelium NOAEL (HEC): 8.7
mg/m3
1000 Low

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (20 pp, 147 K) Last Updated: 06/30/1988

WOE Characterization Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Based on increased incidence of nasal tumors in male and female rats and laryngeal tumors in male and female hamsters after inhalation exposure.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (20 pp, 147 K)

Not Assessed under the IRIS Program.


Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (20 pp, 147 K)

Inhalation Unit Risk: 2.2 x 10-6 per µg/m3
Extrapolation Method: Linearized multistage-variable exposure input form (extra risk)
Tumor site(s): Respiratory
Tumor type(s): Nasal squamous cell carcinoma or adenocarcinoma (Woutersen and Appleman, 1984)

Additional EPA toxicity information may be available by visiting the following sites:

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