IRIS

3-Methylphenol

CASRN 108-39-4 | DTXSID6024200

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (16 pp, 125 K) Last Updated: 08/22/1988

System RfD (mg/kg-day) Basis PoD Composite UF Confidence
Nervous 5 x 10 -2 Decreased body weights and neurotoxicity NOAEL : 5.0 x 101
mg/kg-day
1000 Medium

 


Reference Concentration for Inhalation Exposure (RfC) (PDF) (16 pp, 125 K) Last Updated: 04/01/1992
Information reviewed but value not estimated.

 

Cancer Assessment

Weight of Evidence for Cancer (PDF) (16 pp, 125 K) Last Updated: 09/01/1990

WOE Characterization Framework for WOE Characterization
C (Possible human carcinogen) Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Basis:
  • Based on an increased incidence of skin papillomas in mice in an initiation-promotion study. The three cresol isomers produced positive results in genetic toxicity studies both alone and in combination.
  • This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (16 pp, 125 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (16 pp, 125 K)

Not assessed under the IRIS Program.


Additional EPA toxicity information may be available by visiting the following sites:

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