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Methanol

CASRN 67-56-1 | DTXSID2021731

Toxicological Review (PDF) (212 pp, 3.46 M)
IRIS Summary (PDF) (6 pp, 86 K)

On this page:

Key IRIS
Values
Chemical
Documents
Other EPA
Information

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (6 pp, 86 K) Last Updated: 09/30/2013

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Developmental	2	Extra cervical ribs	BMDL ₀₅ (internal): 43.1 mg/L	100	Medium/High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (6 pp, 86 K) Last Updated: 09/30/2013

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous, Developmental	2 x 10 ¹	Reduced brain weight in rat pups at 6 weeks of age	BMDL _1SD (internal): 858 mg-hr/L	100	Medium/High

Cancer Assessment

Weight of Evidence for Cancer (PDF) (6 pp, 86 K)
Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (6 pp, 86 K)

Not assessed under the IRIS Program.

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (6 pp, 86 K)

Not assessed under the IRIS Program.

Chemical Documents

Sep 2013: IRIS Toxicological Review of Methanol (Noncancer) (Final Report) (Report)

Sep 2013: IRIS Toxicological Review of Methanol (Noncancer) (Interagency Science Discussion Draft) (Report)

Nov 2012: IRIS Toxicological Review of Methanol (Noncancer) (Revised External Review Draft) (Report)

Nov 2011: IRIS Toxicological Review of Methanol (Non-Cancer) (External Review Draft; April 2011) (Report)

Nov 2009: IRIS Toxicological Review of Methanol (Interagency Science Consultation Draft) (Report)

Sep 2009: IRIS Toxicological Review of Methanol (External Review Draft; December 2009) (Report)

Other EPA Information

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.